​​Clinical Trials Group 

​CTG publications

2017

Tiruvoipati R, Botha J, Fletcher J, Gangopadhyay H, Majumdar M, Vij S, Paul E, Pilcher D; Australia and New Zealand Intensive Care Society (ANZICS) Clinical Trials Group. Intensive care discharge delay is associated with increased hospital length of stay: A multicentre prospective observational study. PLoS One. 2017 Jul 27;12(7):e0181827. doi: 10.1371/journal.pone.0181827. eCollection 2017. 
PubMed PMID: 28750010; PubMed Central PMCID: PMC5531506.

Cheung W, Myburgh J, McGuinness S, et al. on behalf of the Influenza Pandemic ICU Triage 3 study investigators and the Australian and New Zealand Intensive Care Society Clinical Trials Group. A cross-sectional survey of Australian and New Zealand public opinion on methods to triage intensive care patients in an influenza pandemic.  Critical Care and Resuscitation Sept 2017 Edition.

Cooper DJ, McQuilten ZK, Nichol A, Ady B, Aubron C, Bailey M, Bellomo R, Gantner D, Irving DO, Kaukonen KM, McArthur C, Murray L, Pettilä V, French C; TRANSFUSE Investigators and the Australian and New Zealand Intensive Care Society Clinical Trials Group. Age of Red Cells for Transfusion and Outcomes in Critically Ill Adults. N Engl J Med. 2017 Sep 27. doi: 10.1056/NEJMoa1707572. [Epub ahead of print] PubMed PMID: 28952891.

Litton E, Elliott R, Thompson K, Watts N, Seppelt I, Webb SAR; ANZICS Clinical Trials Group and The George Institute for Global Health. Using Clinically Accessible Tools to Measure Sound Levels and Sleep Disruption in the ICU: A Prospective Multicenter Observational Study. Crit Care Med. 2017 Jun;45(6):966-971. doi: 10.1097/CCM.0000000000002405. PubMed PMID: 28362644.

Billot L, Venkatesh B, Myburgh J, Finfer S, Cohen J, Webb S, McArthur C, Joyce C, Bellomo R, Rhodes A, Perner A, Arabi Y, Rajbhandari D, Glass P, Thompson K, Correa M, Harward M. Statistical analysis plan for the Adjunctive Corticosteroid Treatment in Critically Ill Patients with Septic Shock (ADRENAL) trial. Crit Care Resusc. 2017 Jun;19(2):183-191. PubMed PMID: 28651515.

PRISM Investigators, Rowan KM, Angus DC, Bailey M, Barnato AE, Bellomo R, Canter RR, Coats TJ, Delaney A, Gimbel E, Grieve RD, Harrison DA, Higgins AM, Howe B, Huang DT, Kellum JA, Mouncey PR, Music E, Peake SL, Pike F, Reade MC, Sadique MZ, Singer M, Yealy DM. Early, Goal-Directed Therapy for Septic Shock - A Patient-Level Meta-Analysis. N Engl J Med. 2017 Jun 8;376(23):2223-2234. doi:
10.1056/NEJMoa1701380. Epub 2017 Mar 21. PubMed PMID: 28320242.

Hammond NE, Taylor C, Finfer S, Machado FR, An Y, Billot L, Bloos F, Bozza F, Cavalcanti AB, Correa M, Du B, Hjortrup PB, Li Y, McIntryre L, Saxena M, Schortgen F, Watts NR, Myburgh J; Fluid-TRIPS and Fluidos Investigators; George Institute for Global Health, The ANZICS Clinical Trials Group, BRICNet, and the REVA research Network. Patterns of intravenous fluid resuscitation use in adult intensive care patients between 2007 and 2014: An international cross-sectional study. PLoS One. 2017 May 12;12(5):e0176292. doi:  10.1371/journal.pone.0176292. eCollection 2017. PubMed PMID: 28498856; PubMed Central PMCID:​ PMC5428917.

Young PJ, Bailey MJ, Beasley RW, Freebairn RC, Hammond NE, Haren FM, Harward ML, Henderson SJ, Mackle DM, McArthur CJ, McGuinness SP, Myburgh JA, Saxena MK, Turner A, Webb SA, Bellomo R; The ANZICS Clinical Trials Group. Protocol and statistical analysis plan for the Randomised Evaluation of Active Control of Temperature versus Ordinary Temperature Management (REACTOR) trial. Crit Care Resusc. 2017 Mar;19(1):81-87. PubMed PMID: 28215136.

2016

Bihari S, Watts NR, Seppelt I, Thompson K, Myburgh A, Prakash S and Bersten A for the George Institute of Global Health and the ANZICS Clinical Trials Group. Maintenance Fluid Practices in Intensive Care Units in Australia and New Zealand, Critical Care Resusc, 2016 Jun;18(2):89-94. PMID: 27242106

Straney L, Schibler A, Ganeshalingham A, Alexander J, Festa M, Slater A, MacLaren G, Schlapbach LJ; Australian and New Zealand Intensive Care Society Centre for Outcomes and Resource Evaluation and the Australian and New Zealand Intensive Care Society Paediatric Study Group. Burden and Outcomes of Severe Pertussis Infection in Critically Ill Infants. Pediatric Critical Care Medicine, epub Jun 2016.

IRONMAN Investigators., Litton E, Baker S, Erber WN, Farmer S, Ferrier J, French C, Gummer J, Hawkins D, Higgins A, Hofmann A, De  Keulenaer B, McMorrow J, Olynyk JK, Richards T, Towler S, Trengove R, Webb S; Australian and New Zealand Intensive Care Society Clinical Trials Group. Intravenous iron or placebo for anaemia in intensive care: the IRONMAN multicentre randomized blinded trial : A randomized trial of IV iron in critical illness. Intensive Care Med. 2016 Nov;42(11):1715-1722. PubMed PMID: 27686346.

Reade MC, Eastwood GM, Bellomo R, Bailey M, Bersten A, Cheung B, Davies A, Delaney A, Ghosh A, van Haren F, Harley N, Knight D, McGuinness S, Mulder J, O'Donoghue S, Simpson N, Young P; DahLIA Investigators; Australian and New Zealand Intensive Care Society Clinical Trials Group. Effect of Dexmedetomidine Added to Standard Care on Ventilator-Free Time in Patients With Agitated Delirium: A Randomized Clinical Trial. JAMA. 2016 Apr 12;315(14):1460-8. doi: 10.1001/jama.2016.2707. PubMed PMID: 26975647  http://jama.jamanetwork.com/article.aspx?articleid=2503421

Bandeshe H, Boots R, Dulhunty J, Dunlop R, Holley A, Jarrett P, Gomersall C. D, Lipman J, Lo T, O'Donoghue S, Paratz J, Paterson D, Roberts JA, Starr T, Stephens D, Stuart J, Thomas J, Udy A, White H. Is inhaled prophylactic heparin useful for prevention and Management of Pneumonia in ventilated ICU patients?: The IPHIVAP investigators of the Australian and New Zealand Intensive Care Society Clinical Trials Group. Crit Care Med. 2016. April 9 [Epub ahead of print]. 95–102.

Hodgson CL, Bailey M, Bellomo R, Berney S, Buhr H, Denehy L, Gabbe B, Harrold M, Higgins A, Iwashyna TJ, Papworth R, Parke R, Patman S, Presneill J, Saxena M, Skinner E, Tipping C, Young P, Webb S; Trial of Early Activity and Mobilization Study Investigators. A Binational Multicenter Pilot Feasibility Randomized Controlled Trial of Early Goal-Directed Mobilization in ICU. Crit Care Med. 2016 Mar 10. [Epub ahead of print] PubMed PMID: 26968024.

Sundararajan K, Flabouris A, Thompson C, Seppelt I; George Institute of Global Health; Australian and New Zealand Intensive Care Society Clinical Trials Group Point Prevalence Study Investigators, Hospital overnight and evaluation of systems and timelines study: A point prevalence study of practice in Australia and New Zealand. Resuscitation. 2016 Mar;100:1-5. doi: 10.1016/j.resuscitation.2015.11.029. Epub 2015 Dec 31. PMID: 26748146

Bellani G, Laffey JG, Pham T, Fan E, Brochard L, Esteban A, Gattinoni L, van Haren F, Larsson A, McAuley DF, Ranieri M, Rubenfeld G, Thompson BT, Wrigge H, Slutsky AS, Pesenti A; LUNG SAFE Investigators; ESICM Trials Group. Epidemiology, Patterns of Care, and Mortality for Patients With Acute Respiratory Distress Syndrome in Intensive Care Units in 50 Countries. JAMA. 2016 Feb 23;315(8):788-800. doi: 10.1001/jama.2016.0291. PubMed PMID: 26903337.

Panwar R, Hardie M, Bellomo R, Barrot L, Eastwood GM, Young PJ, Capellier G, Harrigan PW, Bailey M; CLOSE Study Investigators; ANZICS Clinical Trials Group. Conservative versus Liberal Oxygenation Targets for Mechanically Ventilated Patients. A Pilot Multicenter Randomized Controlled Trial. Am J Respir Crit Care Med. 2016 Jan 1;193(1):43-51. doi: 10.1164/rccm.201505-1019OC. PubMed PMID: 26334785.

​2015


Hammond NE, Taylor C, Saxena M, Liu B, Finfer S, Glass P, Seppelt I, Willenberg L, Myburgh J for the George Institute for Global Health and the Australian and New Zealand Intensive Care Society Clinical Trials Group, Resuscitation fluid use in Australian and New Zealand intensive care units between 2007 and 2013, Intens Care Med, 2015, 41(9):1611-9, doi: 10.1007/s00134-015-3878-y. PMID: 26077073

Dulhunty JM, Roberts JA, Davis JS, Webb SA, Bellomo R, Gomersall C, Shirwadkar C, Eastwood GM, Myburgh J, Paterson DL, Starr T, Paul SK, Lipman J; BLING II Investigators for the ANZICS Clinical Trials Group *. A Multicenter Randomized Trial of Continuous versus Intermittent β-Lactam Infusion in Severe Sepsis. Am J  Respir Crit Care Med. 2015 Dec 1;192(11):1298-305. doi: 10.1164/rccm.201505-0857OC. PubMed PMID: 26200166.

Young P, Saxena M, Bellomo R, Freebairn R, Hammond N, van Haren F, Holliday M, Henderson S, Mackle D, McArthur C, McGuinness S, Myburgh J, Weatherall M, Webb S, Beasley R; HEAT Investigators and the Australian and New Zealand Intensive Care Society Clinical Trials Group. Acetaminophen for Fever in Critically Ill Patients with Suspected Infection. N Engl J Med. 2015 Oct 5. [Epub ahead of print] PubMed 
PMID: 26436473. http://www.nejm.org/doi/full/10.1056/NEJMoa1508375

Nichol A, French C, Little L, Haddad S, Presneill J, Arabi Y, Bailey M, Cooper DJ, Duranteau J, Huet O, Mak A, McArthur C, Pettilä V, Skrifvars M, Vallance S, Varma D, Wills J, Bellomo R; EPO-TBI Investigators and the ANZICS Clinical Trials Group. Erythropoietin in traumatic brain injury (EPO-TBI): a double-blind randomised controlled trial. Lancet. 2015 Oct 6. pii: S0140-6736(15)00386-4. doi: 10.1016/S0140-6736(15)00386-4. [Epub ahead of print] PubMed PMID: 26452709.​ 
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(15)00386-4/abstract

Young P, Bailey M, Beasley R, Henderson S, Mackle D, McArthur C, McGuinness S, Mehrtens J, Myburgh J, Psirides A, Reddy S, Bellomo R; SPLIT Investigators; ANZICS CTG. Effect of a Buffered Crystalloid Solution vs Saline on Acute Kidney Injury Among Patients in the Intensive Care Unit: The SPLIT Randomized Clinical Trial. JAMA. 2015 Oct 27;314(16):1701-10. doi: 10.1001/jama.2015.12334. PubMed PMID: 26444692.​ http://jama.jamanetwork.com/article.aspx?articleid=2454911​

Namachivayam S, Alexander J, Slater A, Millar J, Erickson S, Tibballs J, Festa M, Ganu S, Segedin L, Schlapbach L, Williams G, Shann F, Butt W for the Paediatric Study Group and Australian and New Zealand Intensive Care Society. Epidemiology of Paediatric Chronic Critical Illness in Australia and New Zealand. Critical Care Medicine, Sep 2015.

Beca J, McSharry B, Erickson S, Yung M, Schibler A, Slater A, Wilkins B, Skippen P, Williams G, Sherring C, Butt W for the Paediatric Study Group of the Australia and New Zealand Intensive Care Society Clinical Trials Group.  Hypothermia for Traumatic Brain Injury in Children (HiTBIC) - A Phase II Randomized Controlled Trial. Critical Care Medicine, Jul 2015.

Nichol A, Gantner D, Presneill J, Murray L, Trapani T, Bernard S, Cameron P, Capellier G, Forbes A, McArthur C, Newby L, Rashford S, Rosenfeld JV, Smith T, Stephenson M, Varma D, Walker T, Webb S, Cooper DJ. Protocol for a multicentre randomised controlled trial of early and sustained prophylactic hypothermia in the management of traumatic brain injury. Crit Care Resusc. 2015, Jun; 17(2): 92-100.
http://search.informit.com.au/documentSummary;dn=213351651322121;res=IELHEA

NICE-SUGAR Study Investigators for the Australian and New Zealand Intensive Care Society Clinical Trials Group and the Canadian Critical Care Trials Group. Intensive versus conventional glucose control in critically ill patients with traumatic brain injury: longterm follow-up of a subgroup of patients from the NICE-SUGAR study. Intensive Care Med . 2015, Jun; 41(6): 1037-47. Epub 2015 Jun 19.
http://link.springer.com/article/10.1007%2Fs00134-015-3757-6​

Santamaria JD, Duke GJ, Pilcher DV, Cooper DJ, Moran J, Bellomo R; Discharge and Readmission Evaluation (DARE) Study. The timing of discharge from the intensive care unit and subsequent mortality. A prospective, multicenter studyAm J Respir Crit Care Med . 2015, May 1; 191(9): 1033-9.​ http://www.atsjournals.org/doi/abs/10.1164/rccm.201412-2208OC#.VmUK7nYrJhE​​

Krag M, Perner A, Wetterslev J, Wise MP, Borthwick M, Bendel S, McArthur C, Cook D, Nielsen N, Pelosi P, Keus F, Guttormsen AB, Moller AD, Møller MH; SUP-ICU Collaborators. Stress ulcer prophylaxis in the intensive care unit: an international survey of 97 units in 11 countries. Acta Anaesthesiol Scand. 2015, May; 59(5): 576-85.
http://www.researchgate.net/publication/275051679_Stress_ulcer_prophylaxis_in_the_intensive_care_unit_an_international_survey_of_97_units_in_11_countries_Stress_Ulcer_Prophylaxis_in_the_ICU​

Reddy SK, Young PJ, Beasley RW, Mackle DM, McGuinness SP, McArthur CJ, Henderson SJ, Weinberg L, French CJ, Orford NR, Bailey MJ, Bellomo R. Overview of the study protocols and statistical analysis plan for the Saline versus Plasma-Lyte 148 for Intravenous Fluid Therapy (SPLIT) research programCrit Care Resusc. 2015, Mar; 17(1):29-36.
http://cicm.org.au/CICM_Media/CICMSite/CICM-Website/Resources/Publications/CCR%20Journal/Previous%20Editions/December%202014/ccr_16_4_011214-274.pdf

Venkatesh B, Imeson L, Kruger P, Cohen J, Jones M, Bellomo R; Australian and New Zealand Intensive Care Society Clinical Trials Group; STATInS Trial Investigators. Elevated plasmafree cortisol concentrations and ratios are associated with increased mortality even in the presence of statin therapy in patients with severe sepsis. Crit Care Med . 2015, Mar; 43(3): 630-5.

TEAM Study Investigators, Hodgson C, Bellomo R, Berney S, Bailey M, Buhr H, Denehy L, Harrold M, Higgins A, Presneill J, Saxena M, Skinner E, Young P, Webb S. Early mobilization and recovery in mechanically ventilated patients in the ICU: a bi-national, multi-centre,
prospective cohort study. Crit Care. 2015, Feb 26; 19:81.​ http://www.ncbi.nlm.nih.gov/pubmed/25513788​

Lim W, Meade M, Lauzier F, Zarychanski R, Mehta S, Lamontagne F, Dodek P, McIntyre L, Hall R, Heels-Ansdell D, Fowler R, Pai M, Guyatt G, Crowther MA, Warkentin TE, Devereaux PJ, Walter SD, Muscedere J, Herridge M, Turgeon AF, Geerts W, Finfer S, Jacka M, Berwanger O, Ostermann M, Qushmaq I, Friedrich JO, Cook DJ; PROphylaxis for ThromboEmbolism in Critical Care Trial Investigators. Failure of anticoagulant thromboprophylaxis: risk factors in medical-surgical critically ill patients*. Crit Care Med. 2015, Feb; 43(2): 401-10.

Nichol A, French C, Little L, Presneill J, Cooper DJ, Haddad S, Duranteau J, Huet O, Skrifvars M, Arabi Y, Bellomo R; EPO-TBI Investigators and the Australian and New Zealand Intensive Care Society Clinical Trials Group. Erythropoietin in traumatic brain injury: study protocol for a randomised controlled trial. Trials . 2015, Feb 8; 16:39.

2014

Presneill J, Little L, Nichol A, French C, Cooper DJ, Haddad S, Duranteau J, Huet O, Skrifvars M, Arabi Y, Bellomo R, and EPO-TBI Study Investigators on behalf of the ANZICS-Clinical Trials Group. Statistical analysis plan for the Erythropoietin in Traumatic Brain Injury trial: a 
randomised controlled trial of erythropoietin versus placebo in moderate and severe traumatic brain injury. Trials 2014, 15:501​.

Presneill J, Little L, Nichol A, French C, Cooper DJ, Haddad S, Duranteau J, Huet O, Skrifvars M, Arabi Y, Bellomo R, and EPO-TBI Study Investigators on behalf of the ANZICS-Clinical Trials Group. Statistical analysis plan for the Erythropoietin in Traumatic Brain Injury trial: a randomised controlled trial of erythropoietin versus placebo in moderate and severe traumatic brain injury. Trials 2014, 15:501https://trialsjournal.biomedcentral.com/articles/10.1186/1745-6215-15-501 [December 2014]

Kaukonen KM, Bailey M, Ady B, Aubron C, French C, Gantner D, Irving D, Murray L, Nichol A, Pettilä V, McQuilten Z, Cooper DJ. A randomised controlled trial of standard transfusion versus fresher red blood cell use in intensive care (TRANSFUSE): protocol and statistical analysis plan. Crit Care Resusc.​ 2014 Dec;16(4):255-61. PubMed PMID: 25437218.

Litton E, Baker S, Erber W, French C, Ferrier J, Hawkins D, Higgins AM, Hofmann A, Keulenaer BL, Farmer S, McMorrow J, Olynyk J, Richards T, Towler S, Webb S; Australian and New Zealand Intensive Care Society Clinical Trials Group. The IRONMAN trial: a protocol for a multicentre randomised placebo-controlled trial of intravenous iron in intensive care unit patients with anaemia. Crit Care Resusc. 2014, Dec; 16(4): 285-90.

Schlapbach LJ, Straney L, Alexander J, MacLaren G, Festa M, Schibler A, Slater A; ANZICS Paediatric Study Group. Mortality related to invasive infections, sepsis, and septic shock in critically ill children in Australia and New Zealand, 2002-13: a multicentre retrospective cohort study. Lancet Infect Dis . 2015, Jan; 15(1): 46-54. Epub 2014 Dec 1.

Fowler RA, Mittmann N, Geerts WH, Heels-Ansdell D, Gould MK, Guyatt G, Krahn M, Finfer S, Pinto R, Chan B, Ormanidhi O, Arabi Y, Qushmaq I, Rocha MG, Dodek P, McIntyre L, Hall R, Ferguson ND, Mehta S, Marshall JC, Doig CJ, Muscedere J, Jacka MJ, Klinger JR, Vlahakis N, Orford N, Seppelt I, Skrobik YK, Sud S, Cade JF, Cooper J, Cook D; Canadian Critical Care Trials Group and the Australia and New Zealand Intensive Care Society Clinical Trials Group. Economic evaluation of the prophylaxis for thromboembolism in critical care trial (E-PROTECT): study protocol for a randomized controlled trial. Trials. 2014, Dec 20; 15(1): 502.

Brieva J, Coleman N, Lacey J, Harrigan P, Lewin TJ, Carter GL. Prediction of death in less than 60 minutes after withdrawal of cardiorespiratory support in potential organ donors after circulatory deathTransplantation. 2014, Nov 27; 98(10): 1112-8.

Fowler RA, Mittmann N, Geerts W, Heels-Ansdell D, Gould MK, Guyatt G, Krahn M, Finfer S, Pinto R, Chan B, Ormanidhi O, Arabi Y, Qushmaq I, Rocha MG, Dodek P, McIntyre L, Hall R, Ferguson ND, Mehta S, Marshall JC, Doig CJ, Muscedere J, Jacka MJ, Klinger JR, Vlahakis N, Orford N, Seppelt I, Skrobik YK, Sud S, Cade JF, Cooper J, Cook D; Canadian Critical Care Trials Group; Australia and New Zealand Intensive Care Society Clinical Trials Group. Cost-effectiveness of dalteparin vs unfractionated heparin for the prevention of venous thromboembolism in critically ill patients. JAMA. 2014, Nov 26; 312(20): 2135-45.

Shehabi Y, Sterba M, Garrett PM, Rachakonda KS, Stephens D, Harrigan P, Walker A, Bailey MJ, Johnson B, Millis D, Ding G, Peake S, Wong H, Thomas J, Smith K, Forbes L, Hardie M, Micallef S, Fraser JF, the ProGUARD Study Investigators and the ANZICS Clinical Trials Group. Procalcitonin Algorithm in Critically Ill Adults with Undifferentiated Infection or Suspected Sepsis: A Randomized Controlled TrialAm J Respir Crit Care Med . First published online 8 Oct 2014.​ 

ARISE Investigators; ANZICS Clinical Trials Group, Peake SL, Delaney A, Bailey M, Bellomo R, Cameron PA, Cooper DJ, Higgins AM, Holdgate A, Howe BD, Webb SA, Williams P. Goal-directed resuscitation for patients with early septic shock. N Engl J Med. 2014, Oct 16; 371(16): 1496-506. Epub 2014 Oct 1.

Wang AY, Bellomo R, Ninomiya T, Lo S, Cass A, Jardine M, Gallagher M; RENAL Study Investigators; ANZICS Clinical Trials Group. Angiotensin-converting enzyme inhibitor usage and acute kidney injury: a secondary analysis of RENAL study outcomes. Nephrology (Carlton). 2014, Oct; 19(10): 617-22.

Weiss SL, Fitzgerald JC, Faustino EV, Festa MS, Fink EL, Jouvet P, Bush JL, Kissoon N, Marshall J, Nadkarni VM, Thomas NJ; Pediatric Acute Lung Injury and Sepsis Investigators Network and Australia and New Zealand Intensive Care Society Investigators. Understanding the global epidemiology of pediatric critical illness: the power, pitfalls, and practicalities of point prevalence studies. Pediatr Crit Care Med. 2014, Sep; 15(7): 660-6. 

Hammond NE, Billot L, Finfer S, Myburgh J. Individual patient data comparative analysis of hydroxyethyl starch 130/0.4 v 4% albumin for fluid resuscitation in critically ill patients: statistical analysis plan. Crit Care Resusc . 2014, Sep; 16(3): 206-13. 

Jun M, Bellomo R, Cass A, Gallagher M, Lo S, Lee J; Randomized Evaluation of Normal Versus Augmented Level of Replacement Therapy (RENAL) Study Investigators. Timing of renal replacement therapy and patient outcomes in the randomized evaluation of normal versus augmented level of replacement therapy studyCrit Care Med . 2014, Aug; 42(8): 1756-65.​

Bellomo R, Cass A, Cole L, Finfer S, Gallagher M, Lee J, Lo S, McArthur C, McGuinness S, Norton R, Myburgh J, Sheinkestel C. Daily Protein Intake and Patient Outcomes in Severe Acute Kidney Injury: Findings of the Randomized Evaluation of Normal versus Augmented Level of Replacement Therapy (RENAL) Trial. Blood Purif . 2014 Aug 23; 37(4): 325-334. [Epub ahead of print].

Peake SL, Davies AR, Deane AM, Lange K, Moran JL, O’Connor SN, Ridley EJ, Williams PJ, Chapman MJ; TARGET investigators and the Australian and New Zealand Intensive Care Society Clinical Trials Group. Use of a concentrated enteral nutrition solution to increase calorie delivery to critically ill patients: a randomized, double-blind, clinical trial. Am J Clin Nutr . 2014 Aug; 100(2): 616-25. Epub 2014 Jul 2.


Bihari S, Festa M, Peake SL, Seppelt IM, Williams P, Wilkins B, Bersten A. Sodium administration in critically ill paediatric patients in Australia and New Zealand: a multicentre point prevalence study.​ Crit Care Resusc. 2014 Jun;16(2):112-8.

Lamontagne F, McIntyre L, Dodek P, Heels-Ansdell D, Meade M, Pemberton J, Skrobik Y, Seppelt I, Vlahakis NE, Muscedere J, Reece G, Ostermann M, Padayachee S, Alhashemi J, Walsh M, Lewis B, Schiff D, Moody A, Zytaruk N, Leblanc M, Cook DJ; Prophylaxis for Thromboembolism in Critical Care Trial Investigators; Canadian Critical Care Trials Group; Australian and New Zealand Intensive Care Society Clinical Trials Group. Nonleg venous thrombosis in critically ill adults: a nested prospective cohort study. JAMA Intern Med. 2014 May;174(5):689-96. doi:10.1001/jamainternmed. 2014.169.

Gallagher M, Cass A, Bellomo R, Finfer S, Gattas D, Lee J, Lo S, McGuinness S, Myburgh J, Parke R, Rajbhandari D; POST-RENAL Study Investigators and the ANZICS Clinical Trials Group. Long-term survival and dialysis dependency following acute kidney injury in intensive care: extended follow-up of a randomized controlled trial. PLoS Med. 2014 ​Feb 11;11(2):e1001601. doi: 10.1371/journal.pmed.1001601. eCollection 2014 Feb.

Crowther M, Cook D, Guyatt G, Zytaruk N, McDonald E, Williamson D, Albert M, Dodek P, Finfer S, Vallance S, Heels-Ansdell D, McIntyre L, Mehta S, Lamontagne F, Muscedere J, Jacka M, Lesur O, Kutsiogiannis J, Friedrich J, Klinger JR, Qushmaq I, Burry L, Khwaja K, Sheppard JA, Warkentin TE; PROTECT collaborators; Canadian Critical Care Trials Group; Australian and New Zealand Intensive Care Society Clinical Trials Group. Heparin-induced thrombocytopenia in the critically ill: interpreting the 4Ts test in a randomized trial. J Crit Care. 2014 Jun;29(3):470.e7-15. doi:10.1016/j.jcrc.2014.02.004. Epub 2014 Feb 14.

2013

Young PJ, Weatherall M, Saxena MK, Bellomo R, Freebairn RC, Hammond NE, Haren FM, Henderson SJ, McArthur CJ, McGuinness SP, Mackle D, Myburgh JA, Webb SA, Beasley RW; Australian and New Zealand Intensive Care Society Clinical Trials Group. Statistical analysis plan for the HEAT trial: a multicentre randomised placebocontrolled trial of intravenous paracetamol in intensive care unit patients with fever and infection.​ Crit Care Resusc. 2013 Dec;15(4):279-86.

Parke RL, Eastwood GM, McGuinness SP; George Institute for Global Health; Australian and New Zealand Intensive Care Society Clinical Trials Group. Oxygen therapy in nonintubated adult intensive care patients: a point prevalence study. Crit Care Resusc. 2013 Dec;15(4):287-93.

Cook D, Arabi Y, Ferguson N, Heels-Ansdell D, Freitag A, McDonald E, Clarke F, Keenan S, Pagliarello G, Plaxton W, Herridge M, Karachi T, Vallance S, Cade J, Crozier T, Alves da Silva S, Costa Filho R, Brandao N, Watpool I, McArdle T, Hollinger G, Mandourah Y, Al-Hazmi M, Zytaruk N, Adhikari NK; PROTECT Research Coordinators; PROTECT Investigators; Canadian Critical Care Trials Group; Australian and New Zealand Intensive Care Society Clinical Trials Group. Physicians declining patient enrollment in a critical care trial: a case study in thromboprophylaxis. Intensive Care Med. 2013 Dec; 39(12):2115-25.

Brieva J, Coleman N, Lacey J, Harrigan P, Lewin TJ, Carter GL. Prediction of death in less than 60 minutes following withdrawal of cardiorespiratory support in ICUs. Crit Care Med. 2013 Dec;41(12):2677-87. doi: 10.1097/CCM.0b013e3182987f38.

Bihari S, Peake SL, Seppelt I, Williams P, Bersten A; George Institute for Global Health; Australian and New Zealand Intensive Care Society Clinical Trials Group. Sodium administration in critically ill patients in Australia and New Zealand: a multicentre point prevalence study. Crit Care Resusc. 2013 Dec;15(4):294-300.

Berney SC, Harrold M, Webb SA, Seppelt I, Patman S, Thomas PJ, Denehy L. Intensive care unit mobility practices in Australia and New Zealand: a point prevalence study. Crit Care Resusc. 2013 Dec;15(4):260-5.

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Williamson DR, Albert M, Heels-Ansdell D, Arnold DM,Lauzier F, Zarychanski R, Crowther M, Warkentin TE, Dodek P, Cade J, Lesur O, Lim W, Fowler R, Lamontagne F, Langevin S, Freitag A, Muscedere J, Friedrich JO, Geerts W, Burry L, Alhashemi J, Cook D; PROTECT collaborators; Canadian Critical Care Trials Group; Australian and New Zealand Intensive Care Society Clinical Trials Group. Thrombocytopenia in critically ill patients receiving thromboprophylaxis: frequency, risk factors, and outcomes. Chest. 2013 Oct;144(4):1207-15. doi: 10.1378/chest.13-0121.

Warkentin TE, Sheppard JA, Heels-Ansdell D, Marshall JC, McIntyre L, Rocha MG, Mehta S, Davies AR, Bersten AD, Crozier TM, Ernest D, Vlahakis NE, Hall RI, Wood GG, Poirier G, Crowther MA, Cook DJ; Canadian Critical Care Trials Group; Australian and New Zealand Intensive Care Society Clinical Trials Group. Heparin-induced thrombocytopenia in medical surgical critical illness. Chest. 2013 Sep;144(3):848-58. doi:​10.1378/chest.13-0057.

Hammond NE, Saxena MK, Taylor C, Young P, Seppelt I, Glass P, Myburgh J; George Institute for Global Health; Australian and New Zealand Intensive Care Society Clinical Trials Group. Temperature management of non-elective intensive care patients without neurological abnormalities: a point prevalence study of practice in Australia and New Zealand. Crit Care Resusc. 2013 Sep;15(3):228-33.

Elliott D, Aitken LM, Bucknall TK, Seppelt IM, Webb SA, Weisbrodt L, McKinley S; Australian and New Zealand Intensive Care Society Clinical Trials Group; George Institute for Global Health. Patient comfort in the intensive care unit: a multicentre, binational point prevalence study of analgesia, sedation and delirium management. Crit Care Resusc. 2013 Sep;15(3):213-9.

Dulhunty JM, Roberts JA, Davis JS, Webb SA, Bellomo R, Gomersall C, Shirwadkar C, Eastwood GM, Myburgh J, Paterson DL, Starr T, Udy AA, Paul SK, Lipman J; Australian and New Zealand Intensive Care Society Clinical Trials Group; Australasian Society for Infectious Diseases Clinical Research Network. A protocol for a multicentre randomised controlled trial of continuous beta-lactam infusion compared with intermittent beta-lactam dosing in critically ill patients with severe sepsis: the BLING II study.​ Crit Care Resusc. 2013 Sep;15(3):179-85.

Delaney AP, Peake SL, Bellomo R, Cameron P, Holdgate A, Howe B, Higgins A, Presneill J, Webb S; ARISE investigators. The Australasian Resuscitation in Sepsis Evaluation (ARISE) trial statistical analysis plan. Crit Care Resusc. 2013 Sep;15(3):162-71.

Delaney A, Peake SL, Bellomo R, Cameron P, Holdgate A, Howe B, Higgins A, Presneill J, Webb S; ARISE Investigators. Australasian Resuscitation In Sepsis Evaluation trial statistical analysis plan. Emerg Med Australas. 2013 Oct;25(5):406-15. doi: 10.1111/1742-6723.12116. Epub 2013 Sep 9.

Shehabi Y, Bellomo R, Reade MC, Bailey M, Bass F, Howe B, McArthur C, Murray L, Seppelt IM, Webb S, Weisbrodt L; for the Sedation Practice in Intensive Care Evaluation (SPICE) Study Investigators and the Australian and New Zealand Intensive Care Society (ANZICS) Clinical Trials Group. Early Goal-Directed Sedation Versus Standard Sedation in Mechanically Ventilated Critically Ill Patients: A Pilot Study.​ Crit Care Med. 2013 Aug 41(8): 1983-1991.


Doig GS, Simpson F, Sweetman EA, Finfer SR, Cooper DJ, Heighes PT, Davies AR, O'​Leary M, Solano T, Peake S; Early PN Investigators of the ANZICS Clinical Trials Group. Early parenteral nutrition in critically ill patients with short-term relative contraindications to early enteral nutrition: a randomized controlled trial. Journal of the American Medical Association May 2013, 309(20):2130-8.

Cooper DJ, Myburgh J, Heritier S, Finfer S, Bellomo R, Billot L, Murray L, Vallance S; SAFE-TBI Investigators; Australian and New Zealand Intensive Care Society Clinical Trials Group. Albumin resuscitation for traumatic brain injury: is intracranial hypertension the cause of increased mortality? Journal of Neurotrauma April 2013, 30(7):512-8.

Kruger P, Bailey M, Bellomo R, Cooper DJ, Harward M, Higgins A, Howe B, Jones D, Joyce C, Kostner K, McNeil J, Nichol A, Roberts MS, Syres G, Venkatesh B; ANZ-STATInS Investigators, ANZICS Clinical Trials Group. A multicenter randomized trial of atorvastatin therapy in intensive care patients with severe sepsis. American Journal of Respiratory and Critical Care Medicine April 2013, 187(7):743-50.

Potter JE, McKinley S, Delaney A. Research participants'opinions of delayed consent for a randomised controlled trial of glucose control in intensive care. Intensive Care Medicine March 2013, 39(3):472-80.

Bellomo R, Lipcsey M, Calzavacca P, Haase M, Haase-Fielitz A, Licari E, Tee A, Cole L, Cass A, Finfer S, Gallagher M, Lee J, Lo S, McArthur C, McGuinness S, Myburgh J, Scheinkestel C; RENAL Study Investigators and ANZICS Clinical Trials Group. Early acid-base and blood pressure effects of continuous renal replacement therapy intensity in patients with metabolic acidosis. Intensive Care Medicine March 2013, 39(3):429-36.

Smith OM, McDonald E, Zytaruk N, Foster D, Matte A, Clarke F, Meade L, O'Callaghan N, Vallance S, Galt P, Rajbhandari D, Rocha M, Mehta S, Ferguson ND, Hall R, Fowler R, Burns K, Qushmaq I, Ostermann M, Heels-Ansdell D, Cook D; PROTECT Research Coordinators; PROTECT Investigators; Canadian Critical Care Trials Group; Australian New Zealand Intensive Care Society Clinical Trials Group. Rates and determinants of informed consent: a case study of an international thromboprophylaxis trial. Journal of Critical Care February 2013, 28(1):28-39.

 Cook D, McDonald E, Smith O, Zytaruk N, Heels-Ansdell D, Watpool I, McArdle T, Matte A, Clarke F, Vallance S, Finfer S, Galt P, Crozier T, Fowler R, Arabi Y, Woolfe C, Orford N, Hall R, Adhikari NK, Ferland MC, Marshall J, Meade M; The PROTECT Research Coordinators; PROTECT Investigators; Canadian Critical Care Trials Group and the Australian and New Zealand Intensive Care Society Clinical Trials Group. Co-enrollment of critically ill patients into multiple studies: patterns, predictors and consequences. Critical Care January 2013, 17(1):R1.

2012

Young Paul J, Saxena Manoj K, Bellomo Rinaldo, Freebairn Ross C, Hammond Naomi E, van Haren Frank MP, Henderson Seton J, McArthur Colin J, McGuinness Shay P, Mackle Diane, Myburgh John A, Weatherall Mark, Webb Steve AR and Beasley Richard W and the ANZICS Clinical Trials Group. The HEAT trial: a protocol for a multicentre randomised placebo-controlled trial of IV paracetamol in ICU patients with fever and infection. Critical Care and Resucitation; 14: 290-296. December 2012

Myburgh JA, Finfer S, Bellomo R, Billot L, Cass A, Gattas D, Glass P, Lipman J, Liu B, McArthur C, McGuinness S, Rajbhandari D, Taylor CB, Webb SA; CHEST Investigators; Australian and New Zealand Intensive Care Society Clinical Trials Group. Hydroxyethyl starch or saline for fluid resuscitation in intensive care. New England Journal of Medicine November 2012, 367(20):1901-11.

Shehabi Y, Bellomo R, Reade MC, Bailey M, Bass F, Howe B, McArthur C, Seppelt IM, Webb S, Weisbrodt L; Sedation Practice in Intensive Care Evaluation (SPICE) Study Investigators; ANZICS Clinical Trials Group. Early intensive care sedation predicts long-term mortality in ventilated critically ill patients. American Journal of Respiratory and Critical Care Medicine October 2012, 186(8):724-31.

NICE-SUGAR Study Investigators, Finfer S, Liu B, Chittock DR, Norton R, Myburgh JA, McArthur C, Mitchell I, Foster D, Dhingra V, Henderson WR, Ronco JJ, Bellomo R, Cook D, McDonald E, Dodek P, Hébert PC, Heyland DK, Robinson BG. Hypoglycemia and risk of death in critically ill patients. New England Journal of Medicine September 2012, 367(12):1108-18

Young P, Hodgson C, Dulhunty J, Saxena M, Bailey M, Bellomo R, Davies A, Finfer S, Kruger P, Lipman J, Myburgh J, Peake S, Seppelt I, Streat S, Tate R, Webb S; ANZICS Clinical Trials Group. End points for phase II trials in intensive care: recommendations from the Australian and New Zealand Clinical Trials Group consensus panel meeting. Critical Care and Resuscitation September 2012, 14(3):211-5.

Davies AR, Morrison SS, Bailey MJ, Bellomo R, Cooper DJ, Doig GS, Finfer SR, Heyland DK; ENTERIC Study Investigators; ANZICS Clinical Trials Group. A multicenter, randomized controlled trial comparing early nasojejunal with nasogastric nutrition in critical illness. Critical Care Medicine August 2012, 40(8):2342-8.

 Lutz K, Wilton K, Zytaruk N, Julien L, Hall R, Harvey J, Skrobik Y, Vlahakis N, Meade L, Matte A, Meade M, Burns K, Albert M, Cash BB, Vallance S, Klinger J, Heels-Ansdell D, Cook D; PROTECT Investigators in collaboration with the CCCTG and ANZICS-CTG. Research ethics board approval for an international thromboprophylaxis trial. Journal of Critical Care: 27(3):225-31. June 2012

RENAL Replacement Therapy Study Investigators, Bellomo R, Cass A, Cole L, Finfer S, Gallagher M, Lee J, Lo S, McArthur C, McGuinness S, Norton R, Myburgh J, Scheinkestel C, Su S. An observational study fluid balance and patient outcomes in the Randomized Evaluation of Normal vs. Augmented Level of Replacement Therapy trial. Critical Care Medicine; 40(6):1753-60. June 2012

Peake SL, Chapman MJ, Davies AR, Moran JL, O'Connor S, Ridley E, Williams P, The George Institute for Global Health and the Australian and New Zealand Intensive Care Society Clinical Trials Group. Critical Care and Resuscitation: Enteral nutrition in Australian and New Zealand Intensive Care Units: a point prevalence study of energy delivery practices. Critical Care and Resuscitation; 14; 148-153. June 2012

Blyth CC, Webb SA, Kok J, Dwyer DE, van Hal SJ, Foo H, Ginn AN, Kesson AM, Seppelt I, Iredell JR; on behalf of the ANZIC Influenza Investigators and COSI Microbiological Investigators. The impact of bacterial and viral co-infection in severe influenza. Influenza and Other Respiratory Viruses: 10.1111/j.1750-2659.2012.00360.x. [Epub ahead of print] April 2012

Myburgh J, Li Q, Heritier S, Dan A and Parisa Glass on behalf of the Crystalloid Versus Hydroxyethyl Starch Trial (CHEST) Management Committee. Statistical analysis plan for the Crystalloid Versus Hydroxyethyl Starch Trial (CHEST). Critical Care and Resuscitation; 14; 44-52. March 2012

2011

Smith O, Zytaruk N, McDonald E, Foster D, Clarke F, Matte A, Meade L, Godfrey N, Vallance S, Weisbrodt L. Rates and Determinants of Informed Consent in an International Thromboprophylaxis Trial. Critical Care Medicine: 39(12):27, December 2011

Weisbrodt L, McKinley S, Marshall AP, Cole L, Seppelt IM and
Delaney A. Daily Interruption of Sedation in Patients Receiving Mechanical Ventilation. Am J Crit Care, July 2011, Volume 20, No. 4.

Pettila V, Westbrook AJ, Nichol AD, Bailey MJ, Wood EM, Syres G, Phillips, LE, Street A, French C, Murray L, Orford N, Santamaria JD,
Bellomo R, Cooper DJ for the Blood Observational Study Investigators for the ANZICS Clinical Trials Group. Age of red blood cells and mortality in the critically ill. Critical Care 2011, 15:R116 (http://ccforum.com/content/15/2/R116)

Pettila V, Webb SA, Bailey M, Howe B, Seppelt IM, Bellomo R on behalf of the ANZIC Influenza Investigators and Australian New Zealand Intensive Care Society Clinical Trials Group. Acute kidney injury in patients with influenza A (H1N1) 2009. Intensive Care Med 2011; 37: p. 763-7.

Cooper DJ, Rosenfeld JV, Murray L, Arabi YM, Davies AR, D'Urso P, Kossmann T, Ponsford J, Seppelt I, Reilly P and Wolfe R for the DECRA Trial Investigators and the Australian and New Zealand Intensive Care Society Clinical Trials Group. Decompressive Craniectomy in Diffuse Traumatic Brain Injury. N Engl J Med, 2011. 364(16): p. 1493-502.

The Crystalloid versus Hydroxyethyl Starch Trial (CHEST) Management Committee The Crystalloid versus Hydroxyethyl Starch Trial: protocol for a multi-centre randomised controlled trial of fluid resuscitation with 6% hydroxyethyl starch (130/0.4) compared to 0.9% sodium chloride (saline) in intensive care patients on mortality. Intensive Care Med, Volume 37 (5), May 2011, p. 816-823.

Cook D, Meade M, Guyatt G, Walter SD, Heels-Ansdell D, Geerts W, Warkentin TE, Cooper DJ, Zytaruk N, Vallance S, Berwanger O, Rocha M, Qushmaq I, Crowther M. PROphylaxis for ThromboEmbolism in Critical Care Trial protocol and analysis plan. J Crit Care. 2011 Apr;26(2):223.e1-9.

The PROTECT Investigators for the Canadian Critical Care Trials Group and the Australian and New Zealand Intensive Care Society Clinical Trials Group.Dalteparin versus Unfractionated Heparin in Critically Ill Patients. N Engl J Med, March 22, 2011.

Yung M, Slater A, Festa M, Williams G, Erickson S, Pettila V, 
Alexander J, Howe B and Shekerdemian L; Australia and New Zealand Intensive Care Influenza Investigators and the Paediatric Study Group and the Clinical Trials Group of the Australia New Zealand Intensive Care Society. Pandemic H1N1 in children requiring intensive care in Australia and New Zealand during winter 2009. Pediatrics 2011; 127:e156-63.

Davies A, Morrison S, Ridley E, Bailey M, Banks M, Cooper DJ, Hardy  G, McIlroy K and Thomson A for the ASAP Study Investigators. Nutritional therapy in patients with acute pancreatitis requiring critical care unit management: A prospective observational study in Australia and New Zealand. Crit Care Med 2011; 39:462-8.

The SAFE Study Investigators. Impact of albumin compared to saline on organ function and mortality of patients with severe sepsis. Intensive Care Med 2011; 37:86-96

2010

Finfer S, Liu B, Taylor C, Bellomo R, Billot L, Cook D, Du B, McArthur C and Myburgh J for the SAFE TRIPS Investigators. Resuscitation fluid use in critically ill adults: an international cross-sectional study in 391 intensive care units. Critical Care; 15 October 2010; 14:R185.http://ccforum.com/content/14/5/R185

Knight M, Pierce M, Seppelt I, Kurinczuk JJ, Spark P, Brocklehurst P, McLintock C, Sullivan E on behalf of the UK's Obstetric Surveillance System, the ANZIC Influenza Investigators, and the Australasian Maternity Outcomes Surveillance System. Critical illness with AH1N1v influenza in pregnancy: a comparison of two population-based cohorts. BJOG; 13 Oct 2010; Online.

The Blood Observational Study Investigators on behalf of the ANZICS-Clinical Trials Group. Transfusion practice and guidelines in Australian and New Zealand intensive care units. Intensive Care Med; May 2010; Online.

Chen J, Bellomo R, Hillman K, Flabouris A, Finfer S and the MERIT Study Investigators for the Simpson Centre and the ANZICS Clinical Trials Group.Triggers for emergency team activation: A multicenter assessment. J Crit Care; Epub March 1 2010.

Robertson MS, Nichol AD, Higgins AM, Bailey MJ, Presneill JJ, Cooper DJ, Webb SA, McArthur C, MacIsaac CM and the VTE Point Prevalence Investigators for the Australian and New Zealand Intensive Care Research Centre (ANZIC-RC) and the Australian and New Zealand Intensive Care Society Clinical Trials Group (ANZICS CTG). Venous thromboembolism prophylaxis in the critically ill: a point prevalence survey of current practice in Australian and New Zealand intensive care units. Criti Care Resusc; March 2010; 12(1): 9-15

Flabouris A, Chen J, Hillman K, Bellomo R, Finfer S and The MERIT Study Investigators from the Simpson Centre and the ANZICs Clinical Trials Group.Timing and interventions of emergency teams during the MERIT study. Resuscitation; January 2010; 81(1): 25-30.

Bellomo R, Pettilä V, Webb SAR, Bailey M, Howe B and Seppelt IM. Acute Kidney Injury and 2009 H1N1 Influenza-Related Critical Illness. Contrib Nephrol; 2010; 165:310-14.

The ANZIC Influenza Investigators and Australasian Maternity Outcomes Surveillance System. Critical illness due to 2009 A/H1N1 influenza in pregnant and postpartum women: population based cohort study. BMJ, 2010; 340:c1279.

2009

Bellomo R, Morimatsu H, Presneill J, French C, Cole L, Story D, Uchino S, Naka T, Finfer S, Cooper DJ and Myburgh J, on behalf of the SAFE Study Investigators and the Australian and New Zealand Intensive Care Society Clinical Trials Group. Effects of saline or albumin resuscitation on standard coagulation tests. Crit Care Resusc, 2009; 11: 250-256.

Chen J, Flabouris A, Bellomo R, Hillman K, Finfer S, MERIT investigators for the Simpson Centre and the ANZICS Clinical Trial Group. Baseline hospital performance and the impact of medical emergency teams: Modelling vs. conventional subgroup analysis. Trials; December 2009; 10:117.

The ANZIC Influenza Investigators. Critical care services and 2009 H1N1 influenza in Australia and New Zealand. N Engl J Med, November 2009; 361(20):1925-34.

The RENAL Replacement Therapy Study Investigators. Intensity of Continuous Renal-Replacement Therapy in Critically Ill Patients. N Engl J Med. October 2009; 361(17):1627-38.

Webb SAR and Seppelt IM for the ANZIC Influenza Investigators. Pandemic (H1N1) 2009 influenza ("swine flu") in Australian and New Zealand intensive care. Crit Care Resusc. September 2009; 11(3):170-172

NICE-SUGAR Study Investigators, Finfer S, Chittock DR, Su SY, Blair D, Foster D, Dhingra V, Bellomo R, Cook D, Dodek P, Henderson WR, Hébert PC, Heritier S, Heyland DK, McArthur C, McDonald E, Mitchell I, Myburgh JA, Norton R, Potter J, Robinson BG, Ronco JJ. Intensive versus conventional glucose control in critically ill patients. N Engl J Med. Mar 26 2009; 360(13):1283-97. Epub 2009 Mar 24.

Finfer S, Heritier S; NICE Study Management Committee and SUGAR Study Executive Committee. The NICE-SUGAR (Normoglycaemia in Intensive Care Evaluation and Survival Using Glucose Algorithm Regulation) Study: statistical analysis plan. Crit Care Resusc. March 2009; 11(1): 46-57.

Chen J, Hillman K, Bellomo R, Flabouris A, Finfer S, Cretikos M; MERIT Study Investigators for the Simpson Centre; ANZICS Clinical Trials Group.The impact of introducing medical emergency team system on the documentations of vital signs. Resuscitation. Jan 2009; 80(1): 35-43. Epub 2008 Nov 17.

Chen J, Bellomo R, Flabouris A, Hillman K , Finfer S; MERIT Study Investigators for the Simpson Centre; ANZICS Clinical Trials Group. The relationship between early emergency team calls and serious adverse events. Crit Care Med. Jan 2009; 37(1):148-53.

Nichol AD, Cooper DJ, POLAR Study Investigators on behalf of the ANZICS-Clinical Trials Group, EPO Study Investigators on behalf of the ANZICS-Clinical Trials Group. Can we improve neurological outcomes in severe traumatic brain injury? Something old (early prophylactic hypothermia) and something new (erythropoietin). Injury. May 2009; 40(5): 471-8. Epub 2009 Apr 15.

Peake SL, Bailey M, Bellomo R, Cameron PA, Cross A, Delaney A, Finfer S, Higgins A, Jones DA, Myburgh JA, Syres GA, Webb SA, Williams P, ARISE Investigators for the Australian and New Zealand Intensive Care Society Clinical Trials Group. Australasian resuscitation of sepsis evaluation (ARISE): A multi-centre, prospective, inception cohort study. Resuscitation. Jul 2009; 80(7): 811-8. Epub 2009 May 20.

The RENAL Investigators. The Randomized Evaluation of Normal vs. Augmented Level Replacement Therapy (RENAL) Trial: A statistical analysis plan. Crit Care Resusc. 2009; 11:59-66

2008

Chen J, Flabouris A, Bellomo R, Hillman K, Finfer S, MERIT Study Investigators for the Simpson Centre and the ANZICS Clinical Trials Group.Medical Emergency Team System and not-for-resuscitation orders: results from the MERIT study. Resuscitation. Dec 2008; 79(3): 391-7. Epub 2008 Oct 25.

Doig GS, Simpson F, Finfer S, Delaney A, Davies AR, Mitchell I, Dobb G, Nutrition Guidelines Investigators of the ANZICS Clinical Trials Group. Effect of evidence-based feeding guidelines on mortality of critically ill adults: a cluster randomized controlled trial. JAMA. Dec 17 2008; 300(23): 2731-41

The RENAL Study Investigators. Screening and Study Enrolment in the Randomized Evaluation of Normal vs. Augmented Level (RENAL) Replacement Therapy Trial. Blood Purif. 2008; 27: 199-205

The RENAL Study Investigators. Design and Challenges of the Randomized Evaluation of Normal vs. Augmented Level Replacement Therapy (RENAL) Trial: High Dose vs. Standard Dose Hemofiltration in Acute Renal Failure. Blood Purif. 2008;26:407-416

The RENAL Study Investigators. Real replacement therapy for acute kidney injury in Australia and New Zealand intensive care units: a practice survey. Crit Care Resusc. 2008; 10: 225-230

Yung M, Wilkins B, Norton L, Slater A and the Paediatric Study Group of the Australian and New Zealand Intensive Care Society. Glucose control, organ failure and mortality in pediatric intensive care. Pediatr Crit Care Med. 2008; 9(2): 147-52

Cook DJ, Blythe D, Rischbieth A, Hebert PC, Zytaruk N, Menon K, Erikson S, Fowler R, Heels-Ansdell D, Meade MO for the Canadian Critical Care Trials Group and the ANZICS Clinical Trials Group. Enrolment of ICU Patients into Clinical Studies: A Tri-national Survey. Crit Care Med. Jul 2008; 36(7):2100-5 

Dulhunty JM, Lipman J, Finfer S and the Sepsis Study Investigators for the ANZICS Clinical Trials Group. Does severe non-infectious SIRS differ from severe sepsis? Results from a multi-centre Australian and New Zealand intensive care unit study. Intens Care Med. 2008; 34(9):1654-1661.

Myburgh JA, Cooper DJ, Finfer SR, Venkatesh B, Jones D, Higgins A, Bishop N, Higlett T and the Australasian Traumatic Brain Injury Study (ATBIS) Investigators for the ANZICS Clinical Trials Group. Epidemiology and 12-month outcomes from traumatic brain injury in Australia and New Zealand. J Trauma. 2008; 64(4):854–62.

Moran J, Bersten A, Solomon P, Edibam C, Hunt T and the ANZICS Clinical Trials Group. Modelling survival in acute severe illness: Cox versus accelerated failure time models. J Eval Clin Pract. 2008; 14:83-93.

Hicks P and Cooper DJ, Webb SAR, Myburgh JA, Seppelt IM, Peake SL, Joyce C, Stephens DP, Turner A, French C, Hart G, Jenkins IR, Burrell AR on behalf of the ANZICS Board and the ANZICS Clinical Trials Group Executive Committee. The Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008. An assessment by the Australian and New Zealand Intensive Care Society. Anaesth Intensive Care. 2008; 36(2):149-51.

Hicks P, Cooper DJ, Webb SAR, Myburgh JA, Seppelt IM, Peake SL, Joyce C, Stephens DP, Turner A, French C, Hart G, Jenkins IR, Burrell AR on behalf of the ANZICS Board and the ANZICS Clinical Trials Group Executive Committee. The Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008. An assessment by the Australian and New Zealand Intensive Care Society. Crit Care Resusc. 2008; 10:8.

2007

Cretikos MA, Chen J, Hillman KM, Bellomo R, Finfer SR, Flabouris A and The MERIT Study Investigators. The effectiveness of implementation of the medical emergency team (MET) system and factors associated with use during the MERIT study. Crit Care Resusc. 2007; 9(2):206-12.

Cretikos M, Chen J, Hillman K, Bellomo R, Finfer S, Flabouris A and The MERIT Study Investigators. The objective medical emergency team activation criteria: A case-control study. Resuscitation. 2007; 73(1):62-72.

Erickson S, Schibler A, Numa A, Nuthall G, Yung M, Pascoe E, Wilkins B on behalf of the Paediatric Study Group; Australian and New Zealand Intensive Care Society. Acute lung injury in pediatric intensive care in Australia and New Zealand- A prospective, multicenter, observational study. Ped Crit Care Med. 2007; 8(4):317-23.

Jones DA, Cooper DJ, Finfer SR, Bellomo R, Myburgh JA, Higgins A, Peake SL, Jenkins I and McNeil J. Advancing Intensive Care Research in Australia and New Zealand – development of the bi-national ANZIC Research Centre. Crit Care Resusc. 2007; 9(2):198-204.

Myburgh JA, Finfer SR and Bellomo R. The Australian and New Zealand Intensive Care Society Clinical Trials Group. ICU Management. 2007; 7:43-45.

Myburgh JA and Skowronski G. The maturation of academic Intensive Care Medicine in Australia and New Zealand: time to capitalise on progress. Anaesth Intensive Care. 2007, 35:169-170.

The Australasian Resuscitation in Sepsis Evaluation (ARISE) Investigators and the Australian and New Zealand Intensive Care Society (ANZICS) Adult Patient Database (APD) Management Committee. The outcome of sepsis and septic shock presenting to the emergency department in Australia and New Zealand. Crit Care Resusc. 2007; 9(1):8-18.

The SAFE Study Investigators. Saline or albumin for fluid resuscitation in patients with traumatic brain injury. N Engl J Med. 2007; 357(9):874-84.

2006

Bellomo R, Morimatsu H, French C, Cole, L, Story, D, Uchino, S, Naka, T on behalf of the SAFE study investigators. The effects of saline or albumin resuscitation on acid-base status and serum electrolytes. Crit Care Med. 2006; 34(12):2891-2897.

The SAFE Study Investigators. Effect of baseline serum albumin concentration on outcome of resuscitation with albumin or saline in patients in Intensive Care Units: Analysis of data from the Saline versus Albumin Fluid Evaluation (SAFE) Study. BMJ. 2006; 333(7577):1044-1049.

Finfer S, Felton T, Blundell A, Lipman J and the ANZICS Clinical Trials Group Sepsis Investigators. Estimate of the number of patients eligible for treatment with drotrecogin alfa (activated) based on differing international indications: Post-hoc analysis of an inception cohort study in Australia and New Zealand. Anaesth Intensive Care. 2006; 34(2):184-190.

Mitchell I, Finfer S, Bellomo R, Higlett T and the ANZICS Clinical Trials Group Glucose Management Investigators. Management of blood glucose in the critically ill in Australia and New Zealand: A practice survey and inception cohort study. Intensive Care Med. 2006; 32(6):867-74.

Mitchell I, Knight E, Gissane J, Tamhane R, Kolli R, Leditschke A, Bellomo R, Finfer S and the Australia and New Zealand Intensive Care Society Clinical Trials Group. A Phase II Randomised Controlled Trial of Intensive Insulin Therapy in General Intensive Care Patients. Crit Care Resusc. 2006; 8(4):289-93.

2005

The NICE – SUGAR Study Investigators. The Normoglycemia in Intensive Care Evaluation (NICE) (ISRCTN04968275) and Survival Using Glucose Algorithm Regulation (SUGAR) Study: Development, design and conduct of an international multi-center, open label, randomized controlled trial of two target ranges for glycemic control in intensive care unit patients. Am J Respir Crit Care Med. 2005:172; (C) http://ajrccm.atsjournals.org/cgi/data/172/11/1358/DC1/1

Rischbieth A, Blythe D and the Australian and New Zealand Intensive Care Society Clinical Trials Group (ANZICS CTG). Ethical intensive care research: development of an ethics handbook. Crit Care Resusc. 2005; 7(4):310-21.

MERIT study investigators. Introduction of the medical emergency team (MET) system: a cluster-randomised controlled trial. Lancet. 2005; 365:2091-97.

Cook DJ, Rocker G, Meade M, Guyatt G, Geerts W, Anderson D, Skrobik Y, Hebert P, Albert M, Cooper DJ, Bates S, Caco C, Finfer S, Fowler S, Freitag A, Granton J, Jones G, Langevin S, Mehta S, Pagliarello G, Poirier G, Rabbat C, Schiff D, Griffith L, Crowther M for the PROTECT investigators and the Canadian Critical Care Trials Group. Prophylaxis for ThromboEmbolism in Critical Care (PROTECT) Trial: A Pilot Study. J Crit Care. 2005; 20(4):364-372.

Cooper DJ, Bishop N, Cade J, Finfer S, Gallus A, Myburgh J for the Australian and New Zealand Intensive Care Society Clinical Trials Group.Thromboprophylaxis for intensive care patients in Australia and New Zealand: A brief survey report. J Crit Care. 2005; 20(4):354-6. 

Boots R, Lipman J, Bellomo R, Stephens D, Heller RF, for the ANZICS-CTG.The spectrum of practice in the diagnosis and management of pneumonia in patients requiring mechanical ventilation. Australian and New Zealand Practice in Intensive Care (ANZPIC II). Anaesth Intens Care. 2005; 33:87-100. 

Boots R, Lipman J, Bellomo R, Stephens D, Heller RF, for the ANZICS-CTG.Disease risk and mortality prediction in intensive care patients with pneumonia. Australian and New Zealand Practice in Intensive Care (ANZPIC II). Anaesth Intensive Care. 2005; 33:101-111.

Boots R, Lipman J, Bellomo R, Stephens D, Heller RF, for the ANZICS-CTG.Predictors of physician confidence to diagnose pneumonia and determine illness severity in ventilated patients. Australian and New Zealand Practice in Intensive Care (ANZPIC II). Anaesth Intensive Care. 2005; 33:112-119.

2004

Finfer SR, Boyce NW, Norton RN. The SAFE Study: a landmark trial of the safety of albumin in intensive care. Med J Aust. 2004; 181:237-238.

The SAFE Study Investigators. A comparison of Albumin and Saline for Fluid Resuscitation in the Intensive Care Unit (The SAFE Study). N Engl J Med. 2004; 350:2247-2256.

Finfer S, Bellomo R, Lipman J, French C, Dobb G, Myburgh J and the ANZICS Clinical Trials Group Sepsis Investigators. Adult-population incidence of severe sepsis in Australian and New Zealand intensive care units. Intensive Care Med. 2004; 30:589-596.

Kause J, Smith G, Prytherch D, Parr M, Flabouris A, Hillman K for the Intensive Care Society (UK) & Australian and New Zealand Intensive Care Society Clinical Trials Group ACADEAMIA Investigators. A comparison of Antecedents to Cardiac Arrests, Deaths and EMergency Intensive care Admissions in Australia and New Zealand, and the United Kingdom—the ACADEMIA study. Resuscitation. 2004; 62:275-82.

2003

Finfer S, Bellomo R, Myburgh J, Norton R. Efficacy of albumin in critically ill patients: Large trial in Australia and New Zealand may provide an answer. BMJ. 2003; 326:559-560.

ANZICS Clinical Trials Group and Institute for International Health SAFE Study Investigators. The Saline vs. Albumin Fluid Evaluation (SAFE) Study (ISRCTN76588266): Design and conduct of a multi-centre, blinded randomised controlled trial of intravenous fluid resuscitation in critically ill patients. BMJ.com http://bmj.com/cgi/content/full/326/7389/559/DC1 (Accessed 17th March 2003) (C)

2002

French CJ, Bellomo R, Finfer SR, Lipman J, Chapman M, Boyce NW and the ANZICS Clinical Trials Group. Appropriateness of red blood cell transfusion in Australasian intensive Care practice. Med J Aust. 2002; 177:548-55.

Bersten AD, Edibam C, Hunt T, Moran J and the ANZICS CTG. Incidence and Mortality of acute lung injury (ALI) and the Acute Respiratory Distress Syndrome (ARDS) in three Australian states. Am J Respir Crit Care Med. 2002; 165:443-448.

2001

Finfer S, Myburgh J, Bellomo R. The ANZICS Clinical Trials Group 1994-2001: developing a unique research strategy. World Federation Journal of Critical Care. 2001; Congress Edition:14-17.

2000

Bellomo R, Chapman M, Finfer S, Hickling K, Myburgh J and the Australian and New Zealand Intensive Care Society Clinical Trials Group. Low dose dopamine in patients with early renal dysfunction: a placebo controlled randomised trial. Lancet. 2000; 356:2139-2143.

1998

Bellomo R, Bersten AD, Boots RJ, Bristow PJ, Dobb GJ, Finfer SR, McArthur CJ, Richards B, Skowronski GA, The Australian and New Zealand Intensive Care Multicentre Studies Group Investigators. The use of antimicrobials in ten Australian and New Zealand intensive care units. Anaesth Intensive Care. 1998; 26:648-653.​