ANZICS CTG Endorsed Study
Low OxyGen Intervention for Cardiac Arrest injury Limitation (LOGICAL)
Mega ROX Sub Study
In animal models of cardiac arrest with cardiopulmonary resuscitation, liberal provision of oxygen promotes neuronal damage, worsens cerebral metabolic dysfunction, and increases neurological deficit scores compared to conservative oxygen administration. In the Intensive Care Unit Randomised Oxygen trial (ICU-ROX), among patients with suspected hypoxic ischaemic encephalopathy (HIE) following a cardiac arrest, conservative oxygen therapy was associated with decreased day 180 mortality compared to usual (liberal) oxygen therapy (relative risk 0.73; 95% CI, 0.54 to 0.99; P=0.04). The relative risk of surviving with a favourable neurological outcome at 180 days for conservative vs. liberal oxygen therapy patients was 1.23; 95% CI, 0.95 to 1.59; P=0.13. The aim of the Low OxyGen Intervention for Cardiac Arrest injury Limitation (LOGICAL) trial is to test the hypothesis that conservative oxygen therapy increases survival with a favourable neurological outcome at 180 days post randomisation compared to usual (liberal) oxygen therapy.
Adam Deane; Alistair Nichol; Andrew Udy; Anne Mather; Ary Serpa Neto; Carol Hodgson; Christine McDonald; Diane Mackle; Glenn Eastwood; Ed Litton; Ian Seppelt; James Moore; Lisa Higgins; Michael Bailey; Paul Secombe; Sandra Peake; Rachael Parke; Richard Beasley; Rinaldo Bellomo; Seton Henderson; Simon Finfer; Steve Bernard; Tony Trapani
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