ANZICS CTG Endorsed Study

LOGICAL

Low OxyGen Intervention for Cardiac Arrest injury Limitation (LOGICAL)

Study Description

In animal models of cardiac arrest with cardiopulmonary resuscitation, liberal provision of oxygen promotes neuronal damage, worsens cerebral metabolic dysfunction, and increases neurological deficit scores compared to conservative oxygen administration. In the Intensive Care Unit Randomised Oxygen trial (ICU-ROX), among patients with suspected hypoxic ischaemic encephalopathy (HIE) following a cardiac arrest, conservative oxygen therapy was associated with decreased day 180 mortality compared to usual (liberal) oxygen therapy (relative risk 0.73; 95% CI, 0.54 to 0.99; P=0.04). The relative risk of surviving with a favourable neurological outcome at 180 days for conservative vs. liberal oxygen therapy patients was 1.23; 95% CI, 0.95 to 1.59; P=0.13. The aim of the Low OxyGen Intervention for Cardiac Arrest injury Limitation (LOGICAL) trial is to test the hypothesis that conservative oxygen therapy increases survival with a favourable neurological outcome at 180 days post randomisation compared to usual (liberal) oxygen therapy.

Management Committee

Paul Young (Co-chair), Carol Hodgson (Co-chair), Richard Beasley, Rinaldo Bellomo, Steve Bernard, Adam Deane, Glenn Eastwood, Simon Finfer, Seton Henderson, Lisa Higgins, Jessica Kasza, Diane Mackle, Christine McDonald, Anne Mather, James Moore, Stacey Morgan, Alistair Nichol, Rachael Parke, Sandra Peake, Ary Serpa Neto, Paul Secombe, Ian Seppelt, Tony Trapani, Andrew Udy

Administering Institution

MRINZ

Sample Size

1400 patients

Funding 

NHMRC, Health Research Council of NZ

Reference

CTG2021-08, CTRN12621000518864

Contact

Diane Mackle (email)