ANZICS CTG Endorsed Study
An inception cohort study comparing oxygen practices in mechanically ventilated patients in ANZ ICUs which participate in the ICU-ROX trial, with patients in ICUs which do not
The ICU-ROX TRIPS inception cohort study is part of a programme of research assessing whether participating in the ICU-ROX trial changes attitudes and practices with regard to oxygen therapy, compared to the practices of ICUs which do not participate in ICU-ROX.
Our hypothesis is that for ICUs which participate in the ICU-ROX trial, the proportion of time patients who are mechanically ventilated spend breathing 21% oxygen (room air) will increase but that this practice change will not occur in ANZ ICUs that do not participate.
The study will be collected at three timepoints: (i) before ICU-ROX starts as baseline; (ii) after ICU-ROX is completed, but before it is published; and (iii) 6-12 months after the publication of the results of ICU-ROX.
Diane Mackle (Chair and Project Manager), Richard Beasley, Rinaldo Bellomo, Victoria Bennett, Adam Deane, Glenn Eastwood, Simon Finfer, Ross Freebairn, Ed Litton, Colin McArthur, Shay McGuinness, Kathy Nelson, Rakshit Panwar, and Paul Young.
Medical Research Institute of New Zealand
ANZIC Research Centre
642 patients (214 at 3 time points)
Health Research Council of NZ – Clinical Training Fellowship – $250,000
Project Status as of June 2018
The first phase of ICU-ROX TRIPS (pre-ICU-ROX trial) is now complete. As the ICU-ROX trial has just completed enrolment, the second phase (after ICU-ROX finishes but prior to publication) will commence in the next 1-2 months.
Diane Mackle (email)