Current Active Endorsed Research

Current Active Endorsed Research

ANZICS CTG Current Research

You can select the short title below for more information on the study.

Set up phase (12)
Study number Short name Study title

Australasian resuscitation in sepsis evaluation: fluids


Blend to Limit oxygen in ECMO: A randomised controlled registry trial


Brain oxygen neuromonitoring in Australia and New Zealand assessment trial

CTG 1718-06 CLIP II

A phase III multicentre blinded randomised controlled clinical non-inferiority trial of cryopreserved platelets vs. conventional liquid-stored platelets for the management of post-surgical bleeding.  The cryopreserved vs. liquid platelets trial


The clinical outcomes measurement in perioperative medicine, anaesthesia & surgery study

CTG1617-11 DiCE

Perioperative dexmedetomidine in high risk cardiac surgery evaluation


A prospective, multicentre, randomised, doubleblind placebo controlled, stratified phase III trial of epoetin alfa vs. placebo in critically ill trauma patients


A randomised controlled trial of a heparin low dose protocol versus therapeutic dose heparin in patients on veno-venous extra corporeal membrane oxygenation

CTG1920-01 Mega-ROX

The mega randomised registry trial comparing conservative vs. liberal oxygenation targets

CTG1920-02 PAIN ICU Study

PAIN in Survivors of Intensive Care Units (The PAIN-ICU Study): A Prospective, Multi-centre Observational Cohort Study to Determine the Incidence, Risk Factors and Impact of Chronic Pain in Critically Ill Adult Patients Discharged from ICU.


Severe acute respiratory distress syndrome: generating evidence in Australia and New Zealand


Targeted intensive care test ordering cluster trial

Currently recruiting (20)
Study number Short name Study title
CTG1718-03 The BALANCE Study (Supported Study)

Bacteremia antibiotic length actually needed for clinical effectiveness: randomised controlled trial

(was the BALANCE Pilot RCT CTG1516-03)


A phase III randomised controlled trial of continuous beta-lactam infusion compared with intermittent beta-lactam dosing in critically ill patients

CTG1617-10 EPO TBI Long Term Follow Up

Long term effects of erythropoietin in patients with moderate to severe traumatic brain injury. A follow-up study of an international randomised controlled trial

CTG1819-03 The EXCEL Study

A comprehensive national registry on the treatment and outcomes of patients requiring ECMO


Intensive nutrition therapy compared to usual care in critically ill adults: A randomised pilot trial

CTG1819-02 INTUBE (Supported Study)

International Observational Study to Understand the Impact and Best Practices of Airway Management in Critically Ill Patients

CTG 1617-04 LUCID

Liberal glucose control in critically Ill patient with pre-existing type 2 diabetes (LUCID): a phase II multicentre randomised controlled trial

​CTG1617-06 ​NITRIC (Paediatric)

​Nitric oxide on cardio pulmonary bypass in congenital heart disease

CTG1314-05 PATCH

Pre-hospital anti-fibrinolytics for traumatic coagulopathy and haemorrhage

CTG1415-03 PLUS

The Plasma-Lyte 148® vs Saline study


The re-evaluating the inhibition of stress erosions trial

CTG1516‐01 SPRINT‐SARI (Supported Study)

Short Period Incidence Study of Severe Acute Respiratory Infection


Standard versus accelerated initiation of renal replacement therapy in acute kidney injury

CTG1718-01 SuDDICU

A cluster randomised controlled trial of the clinical effectiveness and cost-effectiveness with a contemporaneous study of the ecological impact of selective decontamination of the digestive tract in critically ill patients treated in intensive care units

CTG1415-02 REMAP-CAP (Supported Study)

Randomized, Embedded, Multifactorial Adaptive Platform trial for Community-Acquired Pneumonia

​CTG1617-001 TAME

​Targeted therapeutic mild hypercapnia after resuscitated cardiac arrest: A phase III multi-centre randomised controlled trial


TARGET point prevalence study

CTG1718-07 TARGET Protein Feasibility Trial

TARGET Protein Feasibility Trial

CTG1516-05 TEAM

Treatment of invasively ventilated adults with early activity and mobilisation

CTG1617-08 TTM2 Trial (Supported Study)

Targeted hypothermia versus targeted normothermia after out-of-hospital cardiac arrest 2, a randomised clinical trial

Analysis & reporting (13)
Study number Short name Study title
CTG1213-03 ADRENAL Consent Substudy

A multicentre, prospective, observational study of the process of obtaining consent from potential participants or their substitute decision-makers in the adjunctive corticosteroid treatment in critically ill patients with septic shock (ADRENAL) Study

CTG08-007 ARISE Economic Evaluation

Economic Evaluation of Resuscitation in Sepsis

CTG1314-09 Baby SPICE Pilot

Sedation practice in paediatric intensive care in Australia and New Zealand

​CTG1415-04 ICU-ROX

A phase 2b, multi-centre, randomised, single blinded clinical trial parallel groups comparing liberal vs. conservative oxygen therapy in mechanically ventilated adults in the Intensive Care Unit (ICU).

CTG1617-09 ICU-ROX TRIPS Inception Cohort Study

An inception cohort study comparing oxygen practices in mechanically ventilated patients in ANZ ICUs which participate in the ICU-ROX trial, with patients in ICUs which do not


A multi-centre RCT of open lung strategy including permissive hypercapnia, alveolar recruitment and low airway pressures in patients with ARDS

​CTG1415-01 PEPTIC

A multi-centre, cluster cross over, randomised registry trial comparing the safety and efficacy of proton pump inhibitors with histamine-2 receptor blockers for ulcer prophylaxis in intensive care patients


The Prophylactic hypOthermia trial to Lessen traumatic bRain injury Basal Energy Assessment Research

CTG1213-05 REACT Shock Study

Relative hypotension and acute kidney injury in patients with shock: a prospective multicentre cohort study

CTG1617-03 The REACTOR Trial

Randomised evaluation of active control of temperature vs. ordinary temperature management


Sampling antibiotics in renal replacement therapy

CTG11-05 The RENAL Substudy of POLAR

The RENAL Substudy of POLAR

CTG1718-02 WEAN SAFE (Supported Study)

Worldwide assessment of separation of patients from ventilatory assistance