Current Active Endorsed Research

ANZICS CTG Current Research

You can select the short title below for more information on the study.

Status : Set up phase (11)

Study number	Short name	Study title
CTG1718-04	ARISE FLUIDS	Australasian resuscitation in sepsis evaluation: fluids
CTG1819-05	BLENDER	Blend to Limit oxygen in ECMO: A randomised controlled registry trial
CTG1718-05	BONANZA	Brain oxygen neuromonitoring in Australia and New Zealand assessment trial
CTG 1718-06	CLIP II	A phase III multicentre blinded randomised controlled clinical non-inferiority trial of cryopreserved platelets vs. conventional liquid-stored platelets for the management of post-surgical bleeding. The cryopreserved vs. liquid platelets trial
CTG1819-08	COMPASS	The clinical outcomes measurement in perioperative medicine, anaesthesia & surgery study
CTG1617-11	DiCE	Perioperative dexmedetomidine in high risk cardiac surgery evaluation
CTG1617-05	EPO TRAUMA	A prospective, multicentre, randomised, doubleblind placebo controlled, stratified phase III trial of epoetin alfa vs. placebo in critically ill trauma patients
CTG1617-07	HELP-ECMO	A randomised controlled trial of a heparin low dose protocol versus therapeutic dose heparin in patients on veno-venous extra corporeal membrane oxygenation
CTG1920-01	Mega-ROX	The mega randomised registry trial comparing conservative vs. liberal oxygenation targets
CTG1819-04	SAGE-ANZ	Severe acute respiratory distress syndrome: generating evidence in Australia and New Zealand
CTG1819-06	TICTOC	Targeted intensive care test ordering cluster trial

Status : Currently recruiting (20)

Study number	Short name	Study title
CTG1718-03	The BALANCE Study (Supported Study)	Bacteremia antibiotic length actually needed for clinical effectiveness: randomised controlled trial (was the BALANCE Pilot RCT CTG1516-03)
CTG1516-04	BLING III	A phase III randomised controlled trial of continuous beta-lactam infusion compared with intermittent beta-lactam dosing in critically ill patients
CTG1617-10	EPO TBI Long Term Follow Up	Long term effects of erythropoietin in patients with moderate to severe traumatic brain injury. A follow-up study of an international randomised controlled trial
CTG1819-03	The EXCEL Study	A comprehensive national registry on the treatment and outcomes of patients requiring ECMO
CTG1718-10	INTENT	Intensive nutrition therapy compared to usual care in critically ill adults: A randomised pilot trial
CTG1819-02	INTUBE (Supported Study)	International Observational Study to Understand the Impact and Best Practices of Airway Management in Critically Ill Patients
CTG 1617-04	LUCID	Liberal glucose control in critically Ill patient with pre-existing type 2 diabetes (LUCID): a phase II multicentre randomised controlled trial
CTG1617-06	NITRIC (Paediatric)	Nitric oxide on cardio pulmonary bypass in congenital heart disease
CTG1314-05	PATCH	Pre-hospital anti-fibrinolytics for traumatic coagulopathy and haemorrhage
CTG1415-03	PLUS	The Plasma-Lyte 148® vs Saline study
CTG1617-02	REVISE	The re-evaluating the inhibition of stress erosions trial
CTG1516‐01	SPRINT‐SARI (Supported Study)	Short Period Incidence Study of Severe Acute Respiratory Infection
CTG1516-02	STARRT-AKI	Standard versus accelerated initiation of renal replacement therapy in acute kidney injury
CTG1718-01	SuDDICU	A cluster randomised controlled trial of the clinical effectiveness and cost-effectiveness with a contemporaneous study of the ecological impact of selective decontamination of the digestive tract in critically ill patients treated in intensive care units
CTG1415-02	REMAP-CAP (Supported Study)	Randomized, Embedded, Multifactorial Adaptive Platform trial for Community-Acquired Pneumonia
CTG1617-001	TAME	Targeted therapeutic mild hypercapnia after resuscitated cardiac arrest: A phase III multi-centre randomised controlled trial
CTG1718-09	TARGET PPP	TARGET point prevalence study
CTG1718-07	TARGET Protein Feasibility Trial	TARGET Protein Feasibility Trial
CTG1516-05	TEAM	Treatment of invasively ventilated adults with early activity and mobilisation
CTG1617-08	TTM2 Trial (Supported Study)	Targeted hypothermia versus targeted normothermia after out-of-hospital cardiac arrest 2, a randomised clinical trial

Status : Analysis & reporting (13)

Study number	Short name	Study title
CTG1213-03	ADRENAL Consent Substudy	A multicentre, prospective, observational study of the process of obtaining consent from potential participants or their substitute decision-makers in the adjunctive corticosteroid treatment in critically ill patients with septic shock (ADRENAL) Study
CTG08-007	ARISE Economic Evaluation	Economic Evaluation of Resuscitation in Sepsis
CTG1314-09	Baby SPICE Pilot	Sedation practice in paediatric intensive care in Australia and New Zealand
CTG1415-04	ICU-ROX	A phase 2b, multi-centre, randomised, single blinded clinical trial parallel groups comparing liberal vs. conservative oxygen therapy in mechanically ventilated adults in the Intensive Care Unit (ICU).
CTG1617-09	ICU-ROX TRIPS Inception Cohort Study	An inception cohort study comparing oxygen practices in mechanically ventilated patients in ANZ ICUs which participate in the ICU-ROX trial, with patients in ICUs which do not
CTG10-008	PHARLAP	A multi-centre RCT of open lung strategy including permissive hypercapnia, alveolar recruitment and low airway pressures in patients with ARDS
CTG1415-01	PEPTIC	A multi-centre, cluster cross over, randomised registry trial comparing the safety and efficacy of proton pump inhibitors with histamine-2 receptor blockers for ulcer prophylaxis in intensive care patients
CTG10-05	POLAR BEAR	The Prophylactic hypOthermia trial to Lessen traumatic bRain injury Basal Energy Assessment Research
CTG1213-05	REACT Shock Study	Relative hypotension and acute kidney injury in patients with shock: a prospective multicentre cohort study
CTG1617-03	The REACTOR Trial	Randomised evaluation of active control of temperature vs. ordinary temperature management
CTG1314-04	SMARRT	Sampling antibiotics in renal replacement therapy
CTG11-05	The RENAL Substudy of POLAR	The RENAL Substudy of POLAR
CTG1718-02	WEAN SAFE (Supported Study)	Worldwide assessment of separation of patients from ventilatory assistance