ANZICS CTG Endorsed Study
A phase 2b, multi-centre, randomised, single blinded clinical trial parallel groups comparing liberal vs. conservative oxygen therapy in mechanically ventilated adults in the Intensive Care Unit (ICU).
Study Description
ICU-ROX is a phase 2b, multi-centre, randomised, single blinded clinical trial parallel groups comparing liberal vs. conservative oxygen therapy in mechanically ventilated adults in the Intensive Care Unit (ICU).
Our study hypothesis is that a conservative approach to oxygen therapy, which minimises unnecessary exposure to hyperoxaemia, will increase ventilator-free days compared to a more liberal approach to oxygen therapy which does not specifically aim to avoid exposure to hyperoxaemia.
Management Committee
Paul Young (Chair), Richard Beasley, Rinaldo Bellomo, Victoria Bennett, Adam Deane, Glenn Eastwood, Simon Finfer, Ross Freebairn, Natalie Linke (Project Manager) Ed Litton, Colin McArthur, Shay McGuinness, Diane Mackle (Project Manager), and Rakshit Panwar.
Administering Institution
Medical Research Institute of New Zealand
Collaborators
ANZIC Research Centre, Monash University
Sample Size
1000 patients
Funding
Health Research Council of New Zealand Project Grant NZ$1,404, 525
Reference
CTG1415-04
ACTRN12615000957594
Contact
Paul Young (email)