ANZICS CTG Endorsed Study
Intensive nutrition therapy compared to usual care in critically ill adults: A randomised pilot trial
Large randomised controlled trials (RCTs) investigating nutrition interventions in critical illness have focussed on the ICU admission which occurs early in the illness and is usually short in duration (approximately 5-7 days). It is plausible, that a longer duration of nutrition intervention may have a greater impact on clinical and patient centred outcomes. The Intensive Nutrition care Therapy comparEd to usual care iN criTically ill adults (INTENT) trial will determine if a whole hospital nutrition intervention is feasible and will deliver more total energy compared to usual care. This study is a prospective, multi-centre, unblinded, parallel-group, phase II RCT conducted in 23 hospitals (240 patients) in Australia and New Zealand. Mechanically ventilated critically ill adult patients with at least one organ failure who have been in ICU for 72-120 hours and meet all of the inclusion and none of the exclusion criteria will be randomised to receive either intensive or usual nutrition care. The study period is from randomisation to hospital discharge or study day 28, whichever occurs first and the primary outcome is daily energy delivery from nutrition therapy. Secondary outcomes include daily energy and protein delivery during ICU and in the post-ICU period, duration of ventilation, ventilator free days, total bloodstream infection rate, length of hospital stay.
Prof Marianne Chapman, A/Prof Lee-anne Chapple, A/Prof Adam Deane, Prof Carol Hodgson, Prof Andrea Marshall, Dr Shay McGuinness, A/Prof Rachael Parke, Prof Andrew Udy, Dr Emma Ridley, Mrs Victoria King, Marlene Gojanovic
ANZIC Research Centre
Emma Ridley (email)