ANZICS CTG Endorsed Study

NEPTUNE

NEt ultrafiltration Prescription and Targeting versus Usual. NEt ultrafiltration during continuous renal replacement therapy

Study Description

Net ultrafiltration (NUF) (i.e., fluid removal) during continuous renal replacement therapy (CRRT) enables management of volume status and is supported by international
clinical guidelines. Emerging evidence from epidemiologic studies of critically ill patients with acute kidney injury suggests that higher intensities of NUF (i.e., higher NUF rates)
impair renal recovery and are associated with increased mortality. However, no randomised studies have compared patient outcomes achieved by targeting a moderate
NUF rate to usual care.

Management Committee

Rinaldo Bellomo, Kyle White, Ary Serpa Neto, Adam Deane, Khaled El-Khawas, Craig French, Cameron Knott, Kevin Laupland, Yahya Shehabi, Ravi Tiruvoipati, Andrew Udy, Emily See, Glenn Eastwood

Administering Institution

Austin Health

Sample Size

tba

Funding

Baxter Acute Therapies

Reference

CTG 2122-02, ACTRN12621001566820

Contact

Rinaldo Bellomo (email)

Emily See (email)