ANZICS CTG Supported Study
Randomized, embedded, multifactorial adaptive platform trial for community-acquired pneumonia
Patients with pneumonia (infection of the lungs) who are being treated in an intensive care unit (ICU) will receive many different treatments, as many as 20 or 30. These treatments act together to treat both the infection and its effects on the body. When treating a patient, doctors choose from many different treatments, most of which are known or believed to be safe and effective. However, doctors don’t always know which treatment option is the better one, as individuals or groups of individuals may respond differently. This study aims to help doctors understand which treatments work best.
This study has been designed in a way that allows the information from patients already in the study to help new patients joining the study. Most studies aren’t able to do that.
REMAP-CAP has been designed to:
The primary objective is to determine the impact on 90 day mortality of:
ANZ Regional Management Committee: Shay McGuinness (Chair), Allen Cheng, Lennie Derde, Andrew Forbes, David Gattas, Cameron Green (Global Project Manager), Stephane Heritier, Lisa Higgins, Peter Kruger, Ed Litton, Colin McArthur, Alistair Nichol, Rachael Parke, Jane Parker (Australian Project Manager), Jeff Presneill, Tony Trapani, Anne Turner (New Zealand Project Manager), Steve Webb and Paul Young.
International Trial Steering Committee: Steve Webb (Chair), Derek Angus, Scott Berry, Zahra Bhimani, Marc Bonten, Frank Brunkhorst, Allen Cheng, Menno De Jong, Lennie Derde, Herman Goossens, Anthony Gordon, Cameron Green (Global Project Manager), Roger Lewis, Ed Litton, John Marshall, Colin McArthur, Shay McGuinness, Srinivas Murthy, Alistair Nichol, Rachael Parke, Jane Parker (Australian Project Manager), Kathy Rowan, Anne Turner (New Zealand Project Manager) and Wilma van Bentum-Puijk.
There are also additional international committees for each domain of the Platform (with ANZ members) and a European Regional Management Committee (with ANZ members).
ANZIC Research Centre, Monash University
Medical Research Institute of New Zealand.
Berry Consulting LLC
Julius Center at the University Medical Center Utrecht
APPRISE Center for Research Excellence
Canadian Critical Care Trials Group
NHMRC – Project Grant – $4,413,145.20
HRC NZ – Programme Grant – NZ$4,800,000
European Union FP7-HEALTH-2013-INNOVATION (2013 – onwards)
Canadian Institutes of Health Research Government- Strategy for Patient-Oriented Research funding (2018 onwards)
Project Status as of June 2019
REMAP-CAP is active at 11 sites in Australia, 7 sites in New Zealand and 14 sites in Europe. Globally 132 patients have been randomised.
Current active Domain:
Angus DC, Berry S, Lewis RJ, Al-Beidh F, Arabi Y, van Bentum-Puijk W, Bhimani Z, Bonten M, Broglio K, Brunkhorst F, Cheng AC, Chiche JD, De Jong M, Detry M, Goossens H, Gordon A, Green C, Higgins AM, Hullegie SJ, Kruger P, Lamontagne F, Litton E, Marshall J, McGlothlin A, McGuinness S, Mouncey P, Murthy S, Nichol A, O’Neill GK, Parke R, Parker J, Rohde G, Rowan K, Turner A, Young P, Derde L, McArthur C, Webb SA. The Randomized Embedded Multifactorial Adaptive Platform for Community-acquired Pneumonia (REMAP-CAP) Study: Rationale and Design. Ann Am Thorac Soc. 2020 Apr 8. doi: 10.1513/AnnalsATS.202003-192SD. [Epub ahead of print] PubMed PMID: 32267771.