ANZICS CTG Supported Study
Randomized, embedded, multifactorial adaptive platform trial for community-acquired pneumonia
Patients with pneumonia (infection of the lungs) who are being treated in an intensive care unit (ICU) will receive many different treatments, as many as 20 or 30. These treatments act together to treat both the infection and its effects on the body. When treating a patient, doctors choose from many different treatments, most of which are known or believed to be safe and effective. However, doctors don’t always know which treatment option is the better one, as individuals or groups of individuals may respond differently. This study aims to help doctors understand which treatments work best.
This study has been designed in a way that allows the information from patients already in the study to help new patients joining the study. Most studies aren’t able to do that.
REMAP-CAP has been designed to:
The primary objective is to determine the impact on 90 day mortality on:
Steve Webb (Chair), Allen Cheng, Lennie Derde, Andrew Forbes, David Gattas, Stephane Heritier, Lisa Higgins, Peter Kruger, Ed Litton, Colin McArthur, Shay McGuinness, Lynnette Murray, Alistair Nichol, Genevieve O’Neill (Project Manager – Australia), Rachael Parke, Jane Parker, Jeff Presneill, Anne Turner (Project Manager – New Zealand), and Paul Young comprise the ANZ Regional Management Committee. There are also additional international committees for each domain of the Platform (with ANZ members), and a European Regional Management Committee (with ANZ members).
ANZIC Research Centre, Monash University, and the Medical Research Institute of New Zealand.
Berry Consulting LLC
Julius Center at the University Medical Center Utrecht
APPRISE Center for Research Excellence
NHMRC – Project Grant – $4,413,145.20
HRCNZ – Programme Grant – $4,800,000 (NZD)
European Union FP7-HEALTH-2013-INNOVATION (2013 – onwards)
Project Status as of June 2018
REMAP-CAP has ethics approvals at hospitals across Australia and New Zealand (ANZ).
Auckland City Hospital Department of Critical Care Medicine in New Zealand has commenced recruitment. Hospitals across ANZ will commence recruitment 2018 winter and summer.
Current active Domain:
Corticosteroid Domain (pending updated protocol incorporating the ADRENAL study findings).
Steve Webb (email)