ANZICS CTG Endorsed Study


Severe acute respiratory distress syndrome: generating evidence in Australia and New Zealand

Update 14/04/2020

The SAGE-ANZ study has been updated to capture data on COVID-19 and is now seeking EOIs from interested sites to participate in the study.

For further information or to express your interest in participating in this study please contact Rachael Parke (NZ sites – or Frank van Haren (Australian sites –

Study Description

Aims: To assess the management of moderate-severe ARDS in intensive care units in Australia and

New Zealand.

Objectives: The objectives of this observational study are to:

  1. Describe management practises and variation in use of ventilator strategies and adjunctive therapies in patients with moderate-severe ARDS
  2. Determine factors in early moderate-severe ARDS associated with survival or need for adjuvant therapy
  3. Evaluate characteristics, management and survival in moderate-severe ARDS patients admitted to ICU compared with patients transferred to referral centres from other sites.
  4. Determine the variability in practise in the use of ventilation strategies and their association with subsequent mortality among patients with moderate-severe ARDS on ECMO.

We hypothesise that this data will give an accurate description of the characteristics and management of adult patients admitted to the ICU in Australia

Management Committee

Rachael Parke (Chair), Samantha Bates, Shailesh Bihari, Amanda Corley, Eileen Gilder, Carol Hodgson, Ed Litton, Colin McArthur, Shay McGuinness, Al Nichol, Jane Parker, Anne Turner, Frank van Haren and Steve Webb.


Intensive Care Unit, Werribee Mercy Hospital, Intensive Care Unit, North Shore Hospital, Cardiothoracic and Vascular Intensive Care Unit, Auckland City Hospital, Department of Critical Care Medicine, Auckland City Hospital, Cairns ICU, Tauranga ICU, Canberra Hospital ICU, Dandenong Hospital, The Prince Charles Hospital, Intensive Care Service, Royal Prince Alfred Hospital, Royal Perth Hospital, Fiona Stanley, The Alfred, Flinders Medical Centre, Middlemore Hospital, Te puna wai ora, Southern Critical Care, Dunedin Hospital, Footscray Hospital (Western Health), Sunshine Hospital (Western Health), Intensive Care Unit, Christchurch Hospital, Timaru Hospital.

Sample Size

600+ patients

Project Status as of June 2019

This study has received ethics approval in New Zealand and Australia and sites are currently finalising local governance approvals. The first sites in New Zealand have commenced screening as of 1st September 2019. A rolling start-up will occur as sites complete governance activities and are able to come on board.




Rachael Parke (email)