ANZICS CTG Endorsed Study
Sampling antibiotics in renal replacement therapy
Inadequate antibiotic therapy is a critical determinant of survival in patients admitted to an Intensive Care Unit (ICU) with overwhelming infection requiring renal replacement therapy (RRT). Guidelines for effective dosing are not available because RRT can be vastly different between ICUs, resulting in significantly different antibiotic pharmacokinetics. Developing an evidence-based antibiotic dosing guideline is of global significance and should be considered a priority to improving clinical outcomes for patients requiring RRT that have infections.
The aim of the SMARRT Study is to develop optimised antibiotic dosing guidelines for ICU patients with life-threatening infections that account for patient characteristics and the type of RRT they are prescribed. This will be achieved through completion of the following aims:
Jason Roberts (Chair), Rinaldo Bellomo, Gordon Choi, Louise Cole, Renae Deans (Project Manager), Melissa Lassig-Smith, Jeffrey Lipman, Sanjoy Paul, Sandra Peake, Michael Roberts, Therese Starr, Dianne Stephens, and John Turnidge.
The University of Queensland
University of Queensland
NHMRC Project Grant $1,034,978.89
Project Status as of June 2019
Manuscript in process.
Jason Roberts (email)