ANZICS CTG Endorsed Study

SODa-BIC RCT

SODium BICarbonate for Metabolic Acidosis in the Intensive Care Unit (SODa-BIC): A multicentre, randomised, double-blind clinical trial

Study Description

SODa-BIC is a collaborative, multicentre, randomised controlled trial investigating the use of sodium bicarbonate for metabolic acidosis.

This trial will compare sodium bicarbonate to 5% dextrose in critically ill patients with metabolic acidosis.  Despite being in common clinical usage, the clinical efficacy of sodium bicarbonate is still uncertain. Previous studies exploring the effects of sodium bicarbonate therapy have been limited and of variable quality. As such, the SODa-BIC study aims to generate more robust evidence, and also to test the efficacy of sodium bicarbonate when administered earlier (pH < 7.30), in patients receiving a vasopressor infusion, compared with 5% dextrose alone.

This trial aims to assess if, among adults in the ICU with metabolic acidosis and receiving vasopressor, an infusion of sodium bicarbonate diluted in 5% dextrose, compared with an infusion of 5% dextrose, reduces Major Adverse Kidney Events within 30 days of randomization.

Management Committee

Dr Ary Serpa Neto, Prof Andrew Udy, Dr Tomoko Fujii, Prof Alistair Nichol, Prof Rinaldo Bellomo, Prof Jamie Cooper, Dr Paul Young, Ms Meredith Young, Ms Mairead McNamara, Mr Tony Trapani, Prof Sandra Peake, Dr Fernando Zampieri, Dr Paul Secombe, Dr Alisa Higgins, Dr Emily See, Prof Carol Hodgson, Ms Pam Taylor

Administering Institution

Australian and New Zealand Intensive Care Research Centre School of Public Health and Preventive Medicine, Monash University

Sample Size

500 patients

Funding

NHMRC

Reference

CTG 2223-03, NCT05697770

Contact

Ary Serpa Neto (email)

Mairead McNamara (email)