ANZICS CTG Supported Study
Short period incidence study of severe acute respiratory infection
Severe acute respiratory infection (SARI) continues to be of major relevance to public health worldwide. In the last 10 years there have been multiple SARI outbreaks around the world. The 2009 H1N1 pandemic was estimated to result in more than 200,000 respiratory deaths globally (1-3). The World Health Organization (WHO) defines SARI as an acute respiratory infection of recent onset (within 10 days) requiring hospitalisation, manifested by fever (≥38oC) or a history of fever and cough (4-7). There is international consensus that it is important to undertake observational studies of patients with SARI as an essential component of pandemic and epidemic research preparedness (8, 9). Due to the severity and communicable nature of SARI – as demonstrated though the 2009 H1N1 pandemic, compounded with annual incidence of SARI during seasonal influenza epidemics – it is clear that investigation of SARI can provide large scale benefits to improve public health. Rapidly obtaining accurate information on the epidemiology of SARI and providing information on how these patients are currently diagnosed and treated is essential. The primary aim of this study is to establish a research response capability for a future epidemic / pandemic through a global SARI observational study. The secondary aim of this study is to investigate the descriptive epidemiology and microbiology profiles of patients with SARI. The tertiary aim of this study is to assess the Ethics, Administrative, Regulatory and Logistic (EARL) barriers to conducting pandemic research on a global level.
The international study is now under the control of Oxford University. Oxford are releasing worldwide COVID data. Much of the data is non-ICU patients.
Over 110,000 patients entered
The Australian portion of the study is all that is reported.
Australian data shall be sent to Oxford. Discussion regarding Data Sharing Agreement continues
SPRINT SARI AUSTRALIA Management
Andrew Udy *, Husna Begum, Tessa Broadley, Aidan Burrell Lewis Campbell, Allen Cheng, Winston Cheung, Jamie Cooper, Simon Erickson, Craig French, Edward Litton, Rick McAllister, Annamaria Palermo, Mark Plummer, Mahesh Ramanan, Benjamin Reddi, Claire Reynolds, Tony Trapani, Shweta Priyadarshini, Hannah Rotherham, Patricia Alliegro, Vicki Papanikolaou, Aaliya Ibrahim, Peinan Zhao and Jodi Dumbrell
ANZIC Research Centre, Monash University
NHMRC, Australian Government, department of Health, ANZIC-RC,
Jodi Dumbrell (email)