ANZICS CTG Supported Study
Bacteremia Antibiotic Length Actually Needed for Clinical Effectiveness: randomised controlled trial
Bloodstream infections are a common and serious problem, affecting 15% of critically ill patients and resulting in increased mortality. Optimal antibiotic treatment duration for these patients has not been studied. The aim of this study is to determine optimal treatment duration for bloodstream infections; maximizing clinical cure while minimizing antimicrobial treatment harms.
The BALANCE pilot RCT is to determine if it feasible to perform the main BALANCE RCT among critically ill patients with bloodstream infection to determine whether shorter duration antibiotic therapy (7 days) is as effective as longer duration antibiotic therapy (14 days)?
We hypothesize that the RCT will be feasible, as determined by:
Nick Daneman, Rob Fowler, Deborah Cook, Steven Reynolds, John Muscedere, Rick Hall, Ruxandra Pinto, Rachael Parke and Asgar Rishu.
Sunnybrook Research Institute, Medical Research Institute of New Zealand
Canadian Critical Care Trials Group
CHUV, Lausanne , Switzerland
King Abdulaziz Medical City Riyadh, KSA
Canadian Institute of Health Research; Ministry of Health and Long-term care alternate funding plan, Canada
Health Research Council of New Zealand
Project Status as of June 2018
CTG ID No 1718-03
ClinicalTrials.gov ID: NCT03005145
Rachael Parke (email)