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The EXCEL Study

ANZICS CTG Endorsed Study

The EXCEL Study

A comprehensive national registry on the treatment and outcomes of patients requiring ECMO

Study Description

The EXCEL Study is a prospective observational national clinical registry. The aim is to generate a national multidisciplinary network of integrated care for patients suffering acute cardiac or respiratory failure or cardiac arrest requiring extracorporeal membrane oxygenation (ECMO) to monitor long term outcomes and identify best practice.

Management Committee

Carol Hodgson (Chair), Shannah Anderson (consumer), Stephen Bernard, Jasmin Board, Dan Brodie, Heidi Buhr, Aidan Burrell, Jamie Cooper, Eddy Fan, John Fraser, David Gattas, Alisa Higgins, Ingrid Hopper, Sue Huckson, Natalie Linke (Project Manager), Ed Litton, Shay McGuiness, Priya Nair, Neil Orford, Rachael Parke, Vincent Pellegrino, David Pilcher, Benjamin Reddi, Dion Stub, Tony Trapani and Andrew Udy.

Administering Institution

ANZIC Research Centre, Monash University

Collaborators

Alfred Health VIC, Fiona Stanley Hospital WA, Royal Prince Alfred Hospital NSW, St Vincent’s Hospital NSW, The Prince Charles Hospital QLD, University Hospital Geelong VIC, Australian and New Zealand Intensive Care Society, Heart Foundation of Australia, Intensive Care Foundation of Australia and New Zealand, International ECMO Network

Sample Size

1005 patients

Funding

National Health and Medical Research Council (Partnership Grant) $692,656.80
Heart Foundation (Partnership Grant) $120,000.00

Project Status 

There are now 26 active sites participating within EXCEL across almost all jurisdictions. The inclusion of the major ECMO centres has resulted in total enrolment of 692 patients to date.                                                                               The process for export of data to the international Extracoporeal Life Support Organisation (ELSO) has been finalised, with a number of sites participating in this process.                                                                                        Specific COVID-19 data points have been added to the EXCEL database in line with those designated by ELSO, with a rolling count of Australian COVID-19 ECMO patients being added to the publicly available EXCEL website.  Several ECMO centres have received approval for commencement within the 2020-2021 window and we anticipate a further two sites joining the registry before the end of this year.                                                                                    Along with this EXCEL has embedded the BLENDER, ECMO ENERGY, OBLEX, ECMO CARD and soon ECMO-Rehab studies within the database.

Reference

CTG1819-03
NCT03793257

Contact

Carol Hodgson (email)